Molecular Biology and Evolution 19:1261-1271 (2002)
© 2002 Society for Molecular Biology and Evolution
DNA Polymorphism at the FRIGIDA Gene in Arabidopsis thaliana: Extensive Nonsynonymous Variation Is Consistent with Local Selection for Flowering Time
Laboratoire Malherbologie et Agronomie, INRA, Dijon Cedex, France
FRIGIDA (FRI) is a major gene involved in the regulation of flowering time in Arabidopsis thaliana. Nucleotide variation at this gene was investigated by sequencing 25 field ecotypes collected from western Europe. Genetic diversity at FRI was characterized by a high number of haplotypes and an excess of low-frequency polymorphisms. A large excess of intraspecific nonsynonymous variation associated with low synonymous variation was detected along the first exon in the FRI gene. In contrast, no excess of nonsynonymous divergence was detected between A. thaliana and A. lyrata. The Tajima and McDonald and Kreitman tests, however, suggested that this gene has evolved in a nonneutral fashion. Nonsynonymous variation included eight loss-of-function mutations that have probably arisen recently and independently in several locations. A phenotypic evaluation of the sequenced ecotypes confirmed that these loss-of-function mutations were associated with an early-flowering phenotype. Taken together, our results suggest that DNA polymorphism at the FRI gene in A. thaliana from western Europe has been shaped by recent positive selection for earliness in a set of isolated populations.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. R. Andersson, C. A. Helliwell, D. J. Bagnall, T. P. Hughes, E. J. Finnegan, W. J. Peacock, and E. S. Dennis The FLX Gene of Arabidopsis is Required for FRI-Dependent Activation of FLC Expression Plant Cell Physiol., February 1, 2008; 49(2): 191 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Kuittinen, A. Niittyvuopio, P. Rinne, and O. Savolainen Natural Variation in Arabidopsis lyrata Vernalization Requirement Conferred by a FRIGIDA Indel Polymorphism Mol. Biol. Evol., February 1, 2008; 25(2): 319 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Scarcelli, J. M. Cheverud, B. A. Schaal, and P. X. Kover Antagonistic pleiotropic effects reduce the potential adaptive value of the FRIGIDA locus PNAS, October 23, 2007; 104(43): 16986 - 16991. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Slotte, K. Holm, L. M. McIntyre, U. Lagercrantz, and M. Lascoux Differential Expression of Genes Important for Adaptation in Capsella bursa-pastoris (Brassicaceae) Plant Physiology, September 1, 2007; 145(1): 160 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Hoballah, T. Gubitz, J. Stuurman, L. Broger, M. Barone, T. Mandel, A. Dell'Olivo, M. Arnold, and C. Kuhlemeier Single Gene-Mediated Shift in Pollinator Attraction in Petunia PLANT CELL, March 1, 2007; 19(3): 779 - 790. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Schlappi FRIGIDA LIKE 2 Is a Functional Allele in Landsberg erecta and Compensates for a Nonsense Allele of FRIGIDA LIKE 1 Plant Physiology, December 1, 2006; 142(4): 1728 - 1738. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Ehrenreich and M. D. Purugganan The molecular genetic basis of plant adaptation Am. J. Botany, July 1, 2006; 93(7): 953 - 962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Lysak, A. Berr, A. Pecinka, R. Schmidt, K. McBreen, and I. Schubert Mechanisms of chromosome number reduction in Arabidopsis thaliana and related Brassicaceae species PNAS, March 28, 2006; 103(13): 5224 - 5229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J. Schmitz, L. Hong, S. Michaels, and R. M. Amasino FRIGIDA-ESSENTIAL 1 interacts genetically with FRIGIDA and FRIGIDA-LIKE 1 to promote the winter-annual habit of Arabidopsis thaliana Development, December 15, 2005; 132(24): 5471 - 5478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Stinchcombe, A. L. Caicedo, R. Hopkins, C. Mays, E. W. Boyd, M. D. Purugganan, and J. Schmitt Vernalization sensitivity in Arabidopsis thaliana (Brassicaceae): the effects of latitude and FLC variation Am. J. Botany, October 1, 2005; 92(10): 1701 - 1707. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Werner, J. O. Borevitz, N. H. Uhlenhaut, J. R. Ecker, J. Chory, and D. Weigel FRIGIDA-Independent Variation in Flowering Time of Natural Arabidopsis thaliana Accessions Genetics, July 1, 2005; 170(3): 1197 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Shindo, M. J. Aranzana, C. Lister, C. Baxter, C. Nicholls, M. Nordborg, and C. Dean Role of FRIGIDA and FLOWERING LOCUS C in Determining Variation in Flowering Time of Arabidopsis Plant Physiology, June 1, 2005; 138(2): 1163 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Werner, J. O. Borevitz, N. Warthmann, G. T. Trainer, J. R. Ecker, J. Chory, and D. Weigel Quantitative trait locus mapping and DNA array hybridization identify an FLM deletion as a cause for natural flowering-time variation PNAS, February 15, 2005; 102(7): 2460 - 2465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Michaels, E. Himelblau, S. Y. Kim, F. M. Schomburg, and R. M. Amasino Integration of Flowering Signals in Winter-Annual Arabidopsis Plant Physiology, January 1, 2005; 137(1): 149 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Caicedo, J. R. Stinchcombe, K. M. Olsen, J. Schmitt, and M. D. Purugganan Epistatic interaction between Arabidopsis FRI and FLC flowering time genes generates a latitudinal cline in a life history trait PNAS, November 2, 2004; 101(44): 15670 - 15675. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hagenblad, C. Tang, J. Molitor, J. Werner, K. Zhao, H. Zheng, P. Marjoram, D. Weigel, and M. Nordborg Haplotype Structure and Phenotypic Associations in the Chromosomal Regions Surrounding Two Arabidopsis thaliana Flowering Time Loci Genetics, November 1, 2004; 168(3): 1627 - 1638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. R. Henderson and C. Dean Control of Arabidopsis flowering: the chill before the bloom Development, August 15, 2004; 131(16): 3829 - 3838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Olsen, S. S. Halldorsdottir, J. R. Stinchcombe, C. Weinig, J. Schmitt, and M. D. Purugganan Linkage Disequilibrium Mapping of Arabidopsis CRY2 Flowering Time Alleles Genetics, July 1, 2004; 167(3): 1361 - 1369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. K. Boss, R. M. Bastow, J. S. Mylne, and C. Dean Multiple Pathways in the Decision to Flower: Enabling, Promoting, and Resetting PLANT CELL, June 1, 2004; 16(suppl_1): S18 - S31. [Full Text] [PDF]
|
|
|
|
|
|
C. Delye, C. Straub, S. Michel, and V. Le Corre Nucleotide Variability at the Acetyl Coenzyme A Carboxylase Gene and the Signature of Herbicide Selection in the Grass Weed Alopecurus myosuroides (Huds.) Mol. Biol. Evol., May 1, 2004; 21(5): 884 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. El-Lithy, E. J.M. Clerkx, G. J. Ruys, M. Koornneef, and D. Vreugdenhil Quantitative Trait Locus Analysis of Growth-Related Traits in a New Arabidopsis Recombinant Inbred Population Plant Physiology, May 1, 2004; 135(1): 444 - 458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Stinchcombe, C. Weinig, M. Ungerer, K. M. Olsen, C. Mays, S. S. Halldorsdottir, M. D. Purugganan, and J. Schmitt A latitudinal cline in flowering time in Arabidopsis thaliana modulated by the flowering time gene FRIGIDA PNAS, March 30, 2004; 101(13): 4712 - 4717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Michaels, I. C. Bezerra, and R. M. Amasino FRIGIDA-related genes are required for the winter-annual habit in Arabidopsis PNAS, March 2, 2004; 101(9): 3281 - 3285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Roux, J. Gasquez, and X. Reboud The Dominance of the Herbicide Resistance Cost in Several Arabidopsis thaliana Mutant Lines Genetics, January 1, 2004; 166(1): 449 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kroymann, S. Donnerhacke, D. Schnabelrauch, and T. Mitchell-Olds Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus PNAS, November 25, 2003; 100(suppl_2): 14587 - 14592. [Abstract] [Full Text]
|
|
|
|
|
|
A. J. Garris, S. R. McCouch, and S. Kresovich Population Structure and Its Effect on Haplotype Diversity and Linkage Disequilibrium Surrounding the xa5 Locus of Rice (Oryza sativa L.) Genetics, October 1, 2003; 165(2): 759 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Michaels, Y. He, K. C. Scortecci, and R. M. Amasino Attenuation of FLOWERING LOCUS C activity as a mechanism for the evolution of summer-annual flowering behavior in Arabidopsis PNAS, August 19, 2003; 100(17): 10102 - 10107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Palaisa, M. Morgante, M. Williams, and A. Rafalski Contrasting Effects of Selection on Sequence Diversity and Linkage Disequilibrium at Two Phytoene Synthase Loci PLANT CELL, August 1, 2003; 15(8): 1795 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gazzani, A. R. Gendall, C. Lister, and C. Dean Analysis of the Molecular Basis of Flowering Time Variation in Arabidopsis Accessions Plant Physiology, June 1, 2003; 132(2): 1107 - 1114. [Abstract] [Full Text] [PDF]
|
|