Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (61)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Eyre-Walker, A.
Right arrow Articles by Gaffney, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Eyre-Walker, A.
Right arrow Articles by Gaffney, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution 19:2142-2149 (2002)
© 2002 Society for Molecular Biology and Evolution

Quantifying the Slightly Deleterious Mutation Model of Molecular Evolution

Adam Eyre-Walker*,2, Peter D. Keightley{dagger}, Nick G. C. Smith*{ddagger} and Daniel Gaffney{dagger}

*Centre for the Study of Evolution & School of Biological Sciences, University of Sussex;
{dagger}Institute of Cell, Animal and Population Biology, University of Edinburgh;
{ddagger}Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University

We have attempted to quantify the frequency and effects of slightly deleterious mutations (SDMs), those that have selective effects close to the reciprocal of the effective population size of a species, by comparing the level of selective constraint in protein-coding genes of related species that have different present-day effective population sizes. In our two comparisons, the species with the smaller effective population size showed lower constraint, implying that SDMs had become fixed. The fixation of SDMs was supported by the observation of a higher fraction of radical to conservative amino acid substitutions in species with smaller effective population sizes. The fraction of strongly deleterious mutations (which rarely become fixed) is >70% in most species. Only ~10% or fewer of mutations seem to behave as SDMs, but SDMs could comprise a substantial fraction of mutations in protein-coding genes that have a chance of becoming fixed between species.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
E. Axelsson and H. Ellegren
Quantification of Adaptive Evolution of Genes Expressed in Avian Brain and the Population Size Effect on the Efficacy of Selection
Mol. Biol. Evol., May 1, 2009; 26(5): 1073 - 1079.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. M. Johnsen, M. Teschke, P. Pavlidis, B. M. McGee, D. Tautz, D. Ginsburg, and J. F. Baines
Selection on cis-Regulatory Variation at B4galnt2 and Its Influence on von Willebrand Factor in House Mice
Mol. Biol. Evol., March 1, 2009; 26(3): 567 - 578.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Osada, S. Mano, and J. Gojobori
Quantifying dominance and deleterious effect on human disease genes
PNAS, January 20, 2009; 106(3): 841 - 846.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
P. R. Haddrill, D. Bachtrog, and P. Andolfatto
Positive and Negative Selection on Noncoding DNA in Drosophila simulans
Mol. Biol. Evol., September 1, 2008; 25(9): 1825 - 1834.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
W. Ferguson, S. Dvora, J. Gallo, A. Orth, and S. Boissinot
Long-Term Balancing Selection at the West Nile Virus Resistance Gene, Oas1b, Maintains Transspecific Polymorphisms in the House Mouse
Mol. Biol. Evol., August 1, 2008; 25(8): 1609 - 1618.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. Charlesworth and A. Eyre-Walker
The McDonald-Kreitman Test and Slightly Deleterious Mutations
Mol. Biol. Evol., June 1, 2008; 25(6): 1007 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. Hasselmann, X. Vekemans, J. Pflugfelder, N. Koeniger, G. Koeniger, S. Tingek, and M. Beye
Evidence for Convergent Nucleotide Evolution and High Allelic Turnover Rates at the complementary sex determiner Gene of Western and Asian Honeybees
Mol. Biol. Evol., April 1, 2008; 25(4): 696 - 708.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. I. Nikolaev, J. I. Montoya-Burgos, K. Popadin, L. Parand, E. H. Margulies, National Institutes of Health Intramural Sequencin, and S. E. Antonarakis
Life-history traits drive the evolutionary rates of mammalian coding and noncoding genomic elements
PNAS, December 18, 2007; 104(51): 20443 - 20448.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
P. D. Keightley and A. Eyre-Walker
Joint Inference of the Distribution of Fitness Effects of Deleterious Mutations and Population Demography Based on Nucleotide Polymorphism Frequencies
Genetics, December 1, 2007; 177(4): 2251 - 2261.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Popadin, L. V. Polishchuk, L. Mamirova, D. Knorre, and K. Gunbin
Accumulation of slightly deleterious mutations in mitochondrial protein-coding genes of large versus small mammals
PNAS, August 14, 2007; 104(33): 13390 - 13395.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
J. F. Baines and B. Harr
Reduced X-Linked Diversity in Derived Populations of House Mice
Genetics, April 1, 2007; 175(4): 1911 - 1921.
[Abstract] [Full Text] [PDF]

Home page
 Proc R Soc BHome page
S. Glemin, E. Bazin, and D. Charlesworth
Impact of mating systems on patterns of sequence polymorphism in flowering plants
Proc R Soc B, December 7, 2006; 273(1604): 3011 - 3019.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
E. J. Vallender and B. T. Lahn
A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway
Hum. Mol. Genet., October 15, 2006; 15(20): 3034 - 3040.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
J. Charlesworth and A. Eyre-Walker
The Rate of Adaptive Evolution in Enteric Bacteria
Mol. Biol. Evol., July 1, 2006; 23(7): 1348 - 1356.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Eyre-Walker, M. Woolfit, and T. Phelps
The Distribution of Fitness Effects of New Deleterious Amino Acid Mutations in Humans
Genetics, June 1, 2006; 173(2): 891 - 900.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Salvador and M. A. Savageau
Evolution of enzymes in a series is driven by dissimilar functional demands
PNAS, February 14, 2006; 103(7): 2226 - 2231.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
P. D. Keightley, G. V. Kryukov, S. Sunyaev, D. L. Halligan, and D. J. Gaffney
Evolutionary constraints in conserved nongenic sequences of mammals
Genome Res., October 1, 2005; 15(10): 1373 - 1378.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
G. V Kryukov, S. Schmidt, and S. Sunyaev
Small fitness effect of mutations in highly conserved non-coding regions
Hum. Mol. Genet., August 1, 2005; 14(15): 2221 - 2229.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Lu and C.-I Wu
Weak selection revealed by the whole-genome comparison of the X chromosome and autosomes of human and chimpanzee
PNAS, March 15, 2005; 102(11): 4063 - 4067.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
S. B. Joseph and D. W. Hall
Spontaneous Mutations in Diploid Saccharomyces cerevisiae: More Beneficial Than Expected
Genetics, December 1, 2004; 168(4): 1817 - 1825.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
N. Bierne and A. Eyre-Walker
The Genomic Rate of Adaptive Amino Acid Substitution in Drosophila
Mol. Biol. Evol., July 1, 2004; 21(7): 1350 - 1360.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
D. M. Webb, L. Cortes-Ortiz, and J. Zhang
Genetic Evidence for the Coexistence of Pheromone Perception and Full Trichromatic Vision in Howler Monkeys
Mol. Biol. Evol., April 1, 2004; 21(4): 697 - 704.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
D. L. Halligan, A. Eyre-Walker, P. Andolfatto, and P. D. Keightley
Patterns of Evolutionary Constraints in Intronic and Intergenic DNA of Drosophila
Genome Res., February 1, 2004; 14(2): 273 - 279.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Kroymann, S. Donnerhacke, D. Schnabelrauch, and T. Mitchell-Olds
Evolutionary dynamics of an Arabidopsis insect resistance quantitative trait locus
PNAS, November 25, 2003; 100(suppl_2): 14587 - 14592.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. D. Keightley and D. J. Gaffney
Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents
PNAS, November 11, 2003; 100(23): 13402 - 13406.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
D. Bachtrog
Protein Evolution and Codon Usage Bias on the Neo-Sex Chromosomes of Drosophila miranda
Genetics, November 1, 2003; 165(3): 1221 - 1232.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Piganeau and A. Eyre-Walker
Estimating the distribution of fitness effects from DNA sequence data: Implications for the molecular clock
PNAS, September 2, 2003; 100(18): 10335 - 10340.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
M. Woolfit and L. Bromham
Increased Rates of Sequence Evolution in Endosymbiotic Bacteria and Fungi with Small Effective Population Sizes
Mol. Biol. Evol., September 1, 2003; 20(9): 1545 - 1555.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Zhang and D. M. Webb
Evolutionary deterioration of the vomeronasal pheromone transduction pathway in catarrhine primates
PNAS, July 8, 2003; 100(14): 8337 - 8341.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
A. Eyre-Walker
Changing Effective Population Size and the McDonald-Kreitman Test
Genetics, December 1, 2002; 162(4): 2017 - 2024.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.