Molecular Biology and Evolution 19:1760-1768 (2002)
© 2002 Society for Molecular Biology and Evolution
Asymmetric Functional Divergence of Duplicate Genes in Yeast
Department of Biology, University of New Mexico
Most duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Here, I present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if asymmetrically diverging duplicate gene pairs show increased robustness to deleterious mutations.
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