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Molecular Biology and Evolution 18:1643-1653 (2001)
© 2001 Society for Molecular Biology and Evolution

Molecular Evolution of Aldolase A Pseudogenes in Mice: Multiple Origins, Subsequent Duplications, and Heterogeneity of Evolutionary Rates

María Noel Cortinas and Enrique P. Lessa

Laboratorio de Evolución, Facultad de Ciencias, Montevideo, Uruguay

The Aldolase multigene family comprises three functional genes (A, B, and C) with tissue-specific expression regulated during ontogeny. DGGE analysis and nucleotide sequencing reveal a family of retropseudogenes of type A in species of Mus. Significant variation in rates of evolution of Aldolase A retropseudogenes is apparent. Our analyses demonstrate that (1) multiple events of retrotransposition are needed to account for the diversity of Aldolase A processed pseudogenes found in mice; (2) some of these sequences have undergone further duplication subsequent to the original retrotransposition event; (3) the patterns of nucleotide substitution are broadly comparable with previous estimates; and (4) estimates of rates of divergence for this array of sequences are up to four times higher than those reported in the literature.


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