Molecular Biology and Evolution 18:172-183 (2001)
© 2001 Society for Molecular Biology and Evolution
ARTICLE |
Testing Multiregionality of Modern Human Origins
Department of Biosystems Science, Graduate University for Advanced Studies, Hayama, Kanagawa, Japan
In order to examine the possibility of multiple founding populations of anatomically modern Homo sapiens, we collected DNA sequence data from 10 X-chromosomal regions, 5 autosomal regions, and 1 Y-chromosomal region, in addition to mitochondrial DNA. Except for five regions which are genealogically uninformative and two other regions for which chimpanzee orthologs are not available, the ancestral sequence and population for each of the remaining regions were successfully inferred. Of these 10 ancestral sequences, 9 occurred in Africa and only 1 occurred in Asia during the Pleistocene. Computer simulation was carried out to quantify the multiregional hypothesis based solely on the premise that there was more than one founding population in the Pleistocene. Allowing the breeding size to vary among the founding populations, the hypothesis may account for the observed African ancestry in 90% of the genomic regions. However, it is required that the founding population in Africa was much larger than that outside Africa. Likelihood estimates of the breeding sizes in the founding populations were more than 9,000 in Africa and less than 1,000 in outside of Africa, although these estimates can be much less biased at the 1% significance level. If the number of African ancestral sequences further increases as more data accumulate in other genomic regions, the conclusion of a single founding population of modern H. sapiens is inevitable.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. P. Cox, F. L. Mendez, T. M. Karafet, M. M. Pilkington, S. B. Kingan, G. Destro-Bisol, B. I. Strassmann, and M. F. Hammer Testing for Archaic Hominin Admixture on the X Chromosome: Model Likelihoods for the Modern Human RRM2P4 Region From Summaries of Genealogical Topology Under the Structured Coalescent Genetics, January 1, 2008; 178(1): 427 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. J. R. Fagundes, N. Ray, M. Beaumont, S. Neuenschwander, F. M. Salzano, S. L. Bonatto, and L. Excoffier Statistical evaluation of alternative models of human evolution PNAS, November 6, 2007; 104(45): 17614 - 17619. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. G. B. Blum and N. A. Rosenberg Estimating the Number of Ancestral Lineages Using a Maximum-Likelihood Method Based on Rejection Sampling Genetics, July 1, 2007; 176(3): 1741 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. R. Rogers, S. Wooding, C. D. Huff, M. A. Batzer, and L. B. Jorde Ancestral Alleles and Population Origins: Inferences Depend on Mutation Rate Mol. Biol. Evol., April 1, 2007; 24(4): 990 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hayakawa, I. Aki, A. Varki, Y. Satta, and N. Takahata Fixation of the Human-Specific CMP-N-Acetylneuraminic Acid Hydroxylase Pseudogene and Implications of Haplotype Diversity for Human Evolution Genetics, February 1, 2006; 172(2): 1139 - 1146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ray, M. Currat, P. Berthier, and L. Excoffier Recovering the geographic origin of early modern humans by realistic and spatially explicit simulations Genome Res., August 1, 2005; 15(8): 1161 - 1167. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garrigan, Z. Mobasher, S. B. Kingan, J. A. Wilder, and M. F. Hammer Deep Haplotype Divergence and Long-Range Linkage Disequilibrium at Xp21.1 Provide Evidence That Humans Descend From a Structured Ancestral Population Genetics, August 1, 2005; 170(4): 1849 - 1856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Garrigan, Z. Mobasher, T. Severson, J. A. Wilder, and M. F. Hammer Evidence for Archaic Asian Ancestry on the Human X Chromosome Mol. Biol. Evol., February 1, 2005; 22(2): 189 - 192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Das, S. Mohanty, and W. Stephan Inferring the Population Structure and Demography of Drosophila ananassae From Multilocus Data Genetics, December 1, 2004; 168(4): 1975 - 1985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka, V. M. Cabrera, A. M. Gonzalez, J. M. Larruga, T. Takeyasu, N. Fuku, L.-J. Guo, R. Hirose, Y. Fujita, M. Kurata, et al. Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan Genome Res., October 1, 2004; 14(10a): 1832 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D.H. Stead, M. E. Hurles, and A. J. Jeffreys Global Haplotype Diversity in the Human Insulin Gene Region Genome Res., September 1, 2003; 13(9): 2101 - 2111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tang, D. O. Siegmund, P. Shen, P. J. Oefner, and M. W. Feldman Frequentist Estimation of Coalescence Times From Nucleotide Sequence Data Using a Tree-Based Partition Genetics, May 1, 2002; 161(1): 447 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.B. Jorde, W.S. Watkins, and M.J. Bamshad Population genomics: a bridge from evolutionary history to genetic medicine Hum. Mol. Genet., October 1, 2001; 10(20): 2199 - 2207. [Abstract] [Full Text] [PDF]
|
|