Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Saunier, K.
Right arrow Articles by Petit, J.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Saunier, K.
Right arrow Articles by Petit, J.-M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution 18:2083-2091 (2001)
© 2001 Society for Molecular Biology and Evolution

Organization of the Bovine {alpha}2-Fucosyltransferase Gene Cluster Suggests that the Sec1 Gene Might Have Been Shaped Through a Nonautonomous L1-Retrotransposition Event Within the Same Locus

Katiana Saunier, Jean-Pierre Barreaud, André Eggen, Rafael Oriol, Hubert Levéziel, Raymond Julien and Jean-Michel Petit

Unité de Génétique Moléculaire Animale, UMR1061 (Institut National de la Recherche Agronomique/Université de Limoges), Institut des Sciences de la Vie et de la Santé, Faculté des Sciences Limoges, Limoges, France;
Laboratoire de Génétique Biochimique et de Cytogénétique, UR339, Institut National de la Recherche Agronomique, Jouy-en-Josas, France;
Glycobiologie Institut National de la Santé et de la Recherche Médicale U504, Université Paris Sud XI, Villejuif, France

By referring to the split coding sequence of the highly conserved {alpha}6-fucosyltransferase gene family (assumed to be representative of the common {alpha}2 and {alpha}6 fucosyltransferase gene ancestor), we have hypothesized that the monoexonic coding sequences of the present {alpha}2-fucosyltransferase genes have been shaped in mammals by several events of retrotransposition and/or duplication. In order to test our hypothesis, we determined the structure of the three bovine {alpha}2-fucosyltransferase genes (bfut1, bfut2, and sec1) and analyzed their characteristics compared with their human counterparts (FUT1, FUT2, and Sec1). We show that in mammals, a complex nonautonomous L1-retrotransposition event occurred within the locus of the {alpha}2-fucosyltransferase ancestor gene itself. A consequence of this event was the processing in Catarrhini of a Sec1 pseudogene via several point mutations.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
R. Mollicone, S. E. H. Moore, N. Bovin, M. Garcia-Rosasco, J.-J. Candelier, I. Martinez-Duncker, and R. Oriol
Activity, Splice Variants, Conserved Peptide Motifs, and Phylogeny of Two New {alpha}1,3-Fucosyltransferase Families (FUT10 and FUT11)
J. Biol. Chem., February 13, 2009; 284(7): 4723 - 4738.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.