Molecular Biology and Evolution 17:1240-1250 (2000)
© 2000 Society for Molecular Biology and Evolution
Regular Article |
Origin and Evolution of the Regulatory Gene male-specific lethal-3
Department of Biological Sciences, Stanford University
Abstract
Dosage compensation in Drosophila is mediated by genes known as "male-specific lethals" (msls). Several msls, including male-specific lethal-3 (msl-3), encode proteins of unknown function. We cloned the Drosophila virilis msl-3 gene. Using the information provided by the sequences of the Drosophila melanogaster and D. virilis genes, we found that sequences of other species can be aligned along their entire lengths with msl-3. Among them, there are genes in yeasts (the Schizosaccharomyces pombe Alp13 gene, as well as a putative Alp13 homolog, found in Saccharomyces cerevisae) and in mammals (MRG15 and MSL3L1 and their relatives) plus uncharacterized sequences of the nematode Caenorhabditis elegans and the plants Arabidopsis thaliana, Lycopersicon esculentum, and Zea mays. A second Drosophila gene of this family has also been found. It is thus likely that msl-3-like genes are present in all eukaryotes. Phylogenetic analyses suggest that msl-3 is orthologous to the mammalian MSL3L1 genes, while the second Drosophila melanogaster gene (which we have called Dm MRG15) is orthologous to mammalian MRG15. These analyses also suggest that the msl-3/MRG15 duplication occurred after the fungus/animal split, while an independent duplication occurred in plants. The proteins encoded by these genes have similar structures, including a putative chromodomain close to their N-terminal end and a putative leucine zipper at their C-terminus. The possible functional roles of these proteins are discussed.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. E. Gelbart and M. I. Kuroda Drosophila dosage compensation: a complex voyage to the X chromosome Development, May 1, 2009; 136(9): 1399 - 1410. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhang, J. Du, B. Sun, X. Dong, G. Xu, J. Zhou, Q. Huang, Q. Liu, Q. Hao, and J. Ding Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3 Nucleic Acids Res., December 2, 2006; 34(22): 6621 - 6628. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Nielsen, D. Nietlispach, A. Buscaino, R. J. Warner, A. Akhtar, A. G. Murzin, N. V. Murzina, and E. D. Laue Structure of the Chromo Barrel Domain from the MOF Acetyltransferase J. Biol. Chem., September 16, 2005; 280(37): 32326 - 32331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Taipale, S. Rea, K. Richter, A. Vilar, P. Lichter, A. Imhof, and A. Akhtar hMOF Histone Acetyltransferase Is Required for Histone H4 Lysine 16 Acetylation in Mammalian Cells Mol. Cell. Biol., August 1, 2005; 25(15): 6798 - 6810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Morales, C. Regnard, A. Izzo, I. Vetter, and P. B. Becker The MRG Domain Mediates the Functional Integration of MSL3 into the Dosage Compensation Complex Mol. Cell. Biol., July 15, 2005; 25(14): 5947 - 5954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tominaga, B. Kirtane, J. G. Jackson, Y. Ikeno, T. Ikeda, C. Hawks, J. R. Smith, M. M. Matzuk, and O. M. Pereira-Smith MRG15 Regulates Embryonic Development and Cell Proliferation Mol. Cell. Biol., April 15, 2005; 25(8): 2924 - 2937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Reid, Z. Moqtaderi, and K. Struhl Eaf3 Regulates the Global Pattern of Histone Acetylation in Saccharomyces cerevisiae Mol. Cell. Biol., January 15, 2004; 24(2): 757 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tajul-Arifin, R. Teasdale, T. Ravasi, D. A. Hume, RIKEN GER Group, GSL Members, and J. S. Mattick Identification and Analysis of Chromodomain-Containing Proteins Encoded in the Mouse Transcriptome Genome Res., June 1, 2003; 13(6): 1416 - 1429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S. Pardo, J. K. Leung, J. C. Lucchesi, and O. M. Pereira-Smith MRG15, a Novel Chromodomain Protein, Is Present in Two Distinct Multiprotein Complexes Involved in Transcriptional Activation J. Biol. Chem., December 20, 2002; 277(52): 50860 - 50866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Yochum and D. E. Ayer Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split Mol. Cell. Biol., November 15, 2002; 22(22): 7868 - 7876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sanjuán and I. Marín Tracing the Origin of the Compensasome: Evolutionary History of DEAH Helicase and MYST Acetyltransferase Gene Families Mol. Biol. Evol., March 1, 2001; 18(3): 330 - 343. [Abstract] [Full Text]
|
|