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Molecular Biology and Evolution 17:1001-1009 (2000)
© 2000 Society for Molecular Biology and Evolution

Article

Removal of Microsatellite Interruptions by DNA Replication Slippage: Phylogenetic Evidence from Drosophila

Bettina Harr, Barbara Zangerl and Christian Schlötterer1,

Institut für Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Austria

Microsatellites are tandem repetitions of short (1–6 bp) motifs. It is widely assumed that microsatellites degenerate through the accumulation of base substitutions in the repeat array. Using a phylogenetic framework, we studied the evolutionary dynamics of interruptions in three Drosophila microsatellite loci. For all three loci, we show that the interruptions in a microsatellite can be lost, resulting in a longer uninterrupted microsatellite stretch. These results indicate that mutations in the microsatellite array do not necessarily lead to decay but may represent only a transition state during the evolution of a microsatellite. Most likely, this purification of interrupted microsatellites is caused by DNA replication slippage.


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