Molecular Biology and Evolution 17:703-717 (2000)
© 2000 Society for Molecular Biology and Evolution
Original Articles |
Contrasting Patterns of Molecular Evolution of the Genes on the New and Old Sex Chromosomes of Drosophila miranda
*Department of Ecology and Evolution, University of Chicago;
and
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, Scotland
Abstract
In organisms with chromosomal sex determination, sex is determined by a set of dimorphic sex chromosomes that are thought to have evolved from a set of originally homologous chromosomes. The chromosome inherited only through the heterogametic sex (the Y chromosome in the case of male heterogamety) often exhibits loss of genetic activity for most of the genes carried on its homolog and is hence referred to as degenerate. The process by which the proto-Y chromosome loses its genetic activity has long been the subject of much speculation. We present a DNA sequence variation analysis of marker genes on the evolving sex chromosomes (neo-sex chromosomes) of Drosophila miranda. Due to its relatively recent origin, the neo-Y chromosome of this species is presumed to be still experiencing the forces responsible for the loss of its genetic activity. Indeed, several previous studies have confirmed the presence of some active loci on this chromosome. The genes on the neo-Y chromosome surveyed in the current study show generally lower levels of variation compared with their counterparts on the neo-X chromosome or an X-linked gene. This is in accord with a reduced effective population size of the neo-Y chromosome. Interestingly, the rate of replacement nucleotide substitutions for the neo-Y linked genes is significantly higher than that for the neo-X linked genes. This is not expected under a model where the faster evolution of the X chromosome is postulated to be the main force driving the degeneration of the Y chromosome.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Bachtrog and P. Andolfatto Selection, Recombination and Demographic History in Drosophila miranda Genetics, December 1, 2006; 174(4): 2045 - 2059. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bartolome and B. Charlesworth Evolution of Amino-Acid Sequences and Codon Usage on the Drosophila miranda Neo-Sex Chromosomes Genetics, December 1, 2006; 174(4): 2033 - 2044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bartolome and B. Charlesworth Rates and Patterns of Chromosomal Evolution in Drosophila pseudoobscura and D. miranda Genetics, June 1, 2006; 173(2): 779 - 791. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bartolome, X. Maside, S. Yi, A. L. Grant, and B. Charlesworth Patterns of Selection on Synonymous and Nonsynonymous Variants in Drosophila miranda Genetics, March 1, 2005; 169(3): 1495 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Filatov Substitution Rates in a New Silene latifolia Sex-Linked Gene, SlssX/Y Mol. Biol. Evol., March 1, 2005; 22(3): 402 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yi, D. Bachtrog, and B. Charlesworth A Survey of Chromosomal and Nucleotide Sequence Variation in Drosophila miranda Genetics, August 1, 2003; 164(4): 1369 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bachtrog Accumulation of Spock and Worf, Two Novel Non-LTR Retrotransposons, on the Neo-Y Chromosome of Drosophila miranda Mol. Biol. Evol., February 1, 2003; 20(2): 173 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. J. Wyckoff, J. Li, and C.-I Wu Molecular Evolution of Functional Genes on the Mammalian Y Chromosome Mol. Biol. Evol., September 1, 2002; 19(9): 1633 - 1636. [Full Text] [PDF]
|
|
|
|
|
|
D. A. Filatov and D. Charlesworth Substitution Rates in the X- and Y-Linked Genes of the Plants, Silene latifolia and S. dioica Mol. Biol. Evol., June 1, 2002; 19(6): 898 - 907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Wolf, J. A. Satkoski, K. White, and L. H. Rieseberg Sex Determination in the Androdioecious Plant Datisca glomerata and Its Dioecious Sister Species D. cannabina Genetics, November 1, 2001; 159(3): 1243 - 1257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Filatov, V. Laporte, C. Vitte, and D. Charlesworth DNA Diversity in Sex-Linked and Autosomal Genes of the Plant Species Silene latifolia and Silene dioica Mol. Biol. Evol., August 1, 2001; 18(8): 1442 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yi and B. Charlesworth A Selective Sweep Associated With a Recent Gene Transposition in Drosophila miranda Genetics, December 1, 2000; 156(4): 1753 - 1763. [Abstract] [Full Text]
|
|