Molecular Biology and Evolution 17:1718-1730 (2000)
© 2000 Society for Molecular Biology and Evolution
ARTICLE |
Evolutionary Relationships Among Proteins Encoded by the Regulator of Complement Activation Gene Cluster
*Department of Biology and Biotechnology, Worcester Polytechnic Institute;
and
Institute of Molecular Medicine for the Prevention of Human Disease, The University of Texas–Houston Health Science Center
Evolutionary relationships among members of the regulator of complement activation (RCA) gene cluster were analyzed using neighbor-joining and parsimony methods of phylogenetic tree inference. We investigated the structural and functional similarities among short consensus repeats (SCRs) of the following human proteins: the 
chain of the C4b-binding protein (C4bp), factor H (FH), factor H–related proteins (FHR-1 through FHR-4), complement receptors type 1 (CR1) and type 2 (CR2), the CR1-like protein (CR1L), membrane cofactor protein (MCP), decay accelerating factor (DAF), and the sand bass proteins, the cofactor protein (SBP1) and its homolog, the cofactor-related protein (SBCRP-1). Also included are the ß chain of the human C4b-binding protein (C4bpß) and the b subunit of human blood-clotting factor XIII (FXIIIb). Our results indicate that the human plasma complement regulators, FH and C4bp, fall into two distinct groups on the basis of their sequence divergence. Homology among RCA proteins is in agreement with their chromosomal location, with the exception of C4bpß. The evolutionary relationships among individual short consensus repeats are confirmed by the exon/intron structure of the RCA members. Structural similarities among repeats of the RCA proteins correlate with their functional activities and demonstrate the importance of the N-terminal SCRs.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Kunert, J. Losse, C. Gruszin, M. Huhn, K. Kaendler, S. Mikkat, D. Volke, R. Hoffmann, T. S. Jokiranta, H. Seeberger, et al. Immune Evasion of the Human Pathogen Pseudomonas aeruginosa: Elongation Factor Tuf Is a Factor H and Plasminogen Binding Protein J. Immunol., September 1, 2007; 179(5): 2979 - 2988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. R. Quin, Q. C. Moore III, and L. S. McDaniel Pneumolysin, PspA, and PspC Contribute to Pneumococcal Evasion of Early Innate Immune Responses during Bacteremia in Mice Infect. Immun., April 1, 2007; 75(4): 2067 - 2070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ngampasutadol, S. Ram, A. M. Blom, H. Jarva, A. E. Jerse, E. Lien, J. Goguen, S. Gulati, and P. A. Rice From The Cover: Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection PNAS, November 22, 2005; 102(47): 17142 - 17147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. C. Soares, D. L. Gerloff, N. R. Syme, A. F.W. Coulson, J. Parkinson, and P. N. Barlow Large-scale modelling as a route to multiple surface comparisons of the CCP module family Protein Eng. Des. Sel., August 1, 2005; 18(8): 379 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oshiumi, K. Shida, R. Goitsuka, Y. Kimura, J. Katoh, S. Ohba, Y. Tamaki, T. Hattori, N. Yamada, N. Inoue, et al. Regulator of Complement Activation (RCA) Locus in Chicken: Identification of Chicken RCA Gene Cluster and Functional RCA Proteins J. Immunol., August 1, 2005; 175(3): 1724 - 1734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. McRae, T. G. Duthy, K. M. Griggs, R. J. Ormsby, P. J. Cowan, B. A. Cromer, W. J. McKinstry, M. W. Parker, B. F. Murphy, and D. L. Gordon Human Factor H-Related Protein 5 Has Cofactor Activity, Inhibits C3 Convertase Activity, Binds Heparin and C-Reactive Protein, and Associates with Lipoprotein J. Immunol., May 15, 2005; 174(10): 6250 - 6256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kimura, N. Inoue, A. Fukui, H. Oshiumi, M. Matsumoto, M. Nonaka, S. Kuratani, T. Fujita, M. Nonaka, and T. Seya A Short Consensus Repeat-Containing Complement Regulatory Protein of Lamprey That Participates in Cleavage of Lamprey Complement 3 J. Immunol., July 15, 2004; 173(2): 1118 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. K. Ganesh, S. A. Smith, G. J. Kotwal, and K. H. M. Murthy Structure of vaccinia complement protein in complex with heparin and potential implications for complement regulation PNAS, June 15, 2004; 101(24): 8924 - 8929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Segerman, J. P. Atkinson, M. Marttila, V. Dennerquist, G. Wadell, and N. Arnberg Adenovirus Type 11 Uses CD46 as a Cellular Receptor J. Virol., September 1, 2003; 77(17): 9183 - 9191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Kuttner-Kondo, L. Mitchell, D. E. Hourcade, and M. E. Medof Characterization of the Active Sites in Decay-Accelerating Factor J. Immunol., August 15, 2001; 167(4): 2164 - 2171. [Abstract] [Full Text] [PDF]
|
|