Molecular Biology and Evolution, Vol 16, 1192-1197, Copyright © 1999 by Society for Molecular Biology and Evolution
RC Karn and MW Nachman
Previous work has shown that the gene for the alpha subunit of androgen-
binding protein, Abpa, may be involved in premating isolation between
different subspecies of the house mouse, Mus musculus. We investigated
patterns of DNA sequence variation at Abpa within and between species of
mice to test several predictions of a model of neutral molecular evolution.
Intraspecific variation among 10 Mus musculus domesticus alleles was
compared with divergence between M. m. domesticus and M. caroli for Abpa
and two X-linked genes, Glra2 and Amg. No variation was observed at Abpa
within M. m. domesticus. The ratio of polymorphism to divergence was
significantly lower at Abpa than at Glra2 and Amg, despite the fact that
all three genes experience similar rates of recombination. Interspecific
comparisons among M. m. domesticus, Mus musculus musculus, Mus musculus
castaneus, Mus spretus, Mus spicilegus, and Mus caroli revealed that the
ratio of nonsynonymous substitutions to synonymous substitutions on a
per-site basis (Ka/Ks) was generally greater than one. The combined
observations of no variation at Abpa within M. m: domesticus and uniformly
high Ka/Ks values between species suggest that positive directional
selection has acted recently at this locus.
ORIGINAL ARTICLE
Reduced nucleotide variability at an androgen-binding protein locus (Abpa) in house mice: evidence for positive natural selection
Department of Biological Sciences, Butler University, USA.
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