Molecular Biology and Evolution, Vol 16, 1117-1124, Copyright © 1999 by Society for Molecular Biology and Evolution
S Wang, C Magoulas and D Hickey
A cluster of four trypsin genes has previously been localized to
cytological position 47D-F of the Drosophila melanogaster genome. One of
these genes had been sequenced, and the presence of the other three genes
was identified by cross-hybridization. Here, we present the DNA sequence of
the entire genomic region encoding these four trypsin genes. In addition to
the four previously inferred genes, we have identified a fifth
trypsin-coding sequence located within this gene cluster. This new gene
shows a high degree of sequence divergence (more than 30%) from the other
four genes, although it retains all of the functional motifs that are
characteristic of trypsin-coding sequences. In order to trace the molecular
evolution of this gene cluster, we isolated and sequenced the homologous
7-kb region from the closely related species Drosophila erecta. A
comparison of the DNA sequences between the two species provides strong
evidence for the concerted evolution of some members of this gene family.
Two genes within the cluster are evolving in concert, while a third gene
appears to be evolving independently. The remaining two genes show an
intermediate pattern of evolution. We propose a simple model, involving
chromosome looping and gene conversion, to explain the relatively complex
patterns of molecular evolution within this gene cluster.
ORIGINAL ARTICLE
Concerted evolution within a trypsin gene cluster in Drosophila
Department of Biology, University of Ottawa, Ontario, Canada.
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