Molecular Biology and Evolution, Vol 16, 773-783, Copyright © 1999 by Society for Molecular Biology and Evolution
NH Smith, EC Holmes, GM Donovan, GA Carpenter and BG Spratt
To understand the pattern of nucleotide sequence variation among bacteria
that frequently exchange chromosomal genes, we analyzed sequences of the
recA, argF, and rho genes, as well as part of the small-subunit (16S) rRNA
gene, from about 50 isolates of human commensal Neisseria species and the
pathogenic N. meningitidis and N. gonorrhoeae. Almost all isolates of these
species could be assigned to five phylogenetic groups that are found for
all genes examined and generally are supported by high bootstrap values. In
contrast, the phylogenetic relationships among groups varied according to
the gene analyzed with notable incongruences involving N. cinerea and N.
lactamica. Further analysis using split decomposition showed that for each
gene, including 16S rRNA, the patterns of sequence divergence within N.
meningitidis and closely related species were inconsistent with a
bifurcating treelike phylogeny and better represented by an interconnected
network. These data indicate that the human commensal Neisseria species can
be separated into discrete groups of related species but that the
relationships both within and among these groups, including those
reconstructed using 16S rRNA, have been distorted by interspecies
recombination events.
ORIGINAL ARTICLE
Networks and groups within the genus Neisseria: analysis of argF, recA, rho, and 16S rRNA sequences from human Neisseria species
School of Biological Sciences, University of Sussex, Brighton, U.K.
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