Molecular Biology and Evolution, Vol 16, 732-740, Copyright © 1999 by Society for Molecular Biology and Evolution
NJ Campbell and SC Barker
We sequenced across all of the gene boundaries in the mitochondrial genome
of the cattle tick, Boophilus microplus, to determine the arrangement of
its genes. The mtDNA of B. microplus has a coding region, composed of
tRNA(Glu) and 60 bp of the 3' end of ND1, that is repeated five times.
Boophilus microplus is the first coelomate animal known to have more than
two copies of a coding sequence. The mitochondrial genome of B. microplus
has other unusual features, including (1) reduced T arms in tRNAs, (2) an
AT bias in codon use, (3) two control regions that have evolved in concert,
(4) three gene rearrangements, and (5) a stem-loop between tRNA(Gln) and
tRNA(Phe). The short T arms and small control regions (CRs) of B. microplus
and other ticks suggest strong selection for small genomes. Imprecise
termination of replication beyond its origin, which can account for the
evolution of tandem repeats of coding regions in other mitochondrial
genomes, cannot explain the evolution of the fivefold repeated sequence in
the mitochondrial genome of B. microplus. Instead, slipped-strand
mispairing or recombination are the most plausible explanations for the
evolution of these tandem repeats.
ORIGINAL ARTICLE
The novel mitochondrial gene arrangement of the cattle tick, Boophilus microplus: fivefold tandem repetition of a coding region
Department of Parasitology, University of Queensland, Brisbane, Australia. n.campbell@mailbox.uq.edu.au
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