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Molecular Biology and Evolution, Vol 16, 719-723, Copyright © 1999 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Evolution of DNA base composition under no-strand-bias conditions when the substitution rates are not constant

JR Lobry and C Lobry
Laboratoire BGBP-CNRS, Universite Claude Bernard, Villeurbanne, France. lobry@biomserv.univ-lyon1.fr

The evolution of DNA base composition evolution is simplified to a six- parameter model when there are no strand biases for mutation and selection. We analyzed the dynamics of this model with special attention to the influence of a change in substitution rates. The G + C content of the DNA sequence tends to an equilibrium value that is controlled by four parameters of the model. When the substitution rates are not constant, the G + C equilibrium position is not constant. The DNA sequence base frequencies always tend to a state in which A = T and G = C within a strand, regardless of substitution rates. This is true even when the substitution rates are not constant over time. This provides a simple way of rejecting the model from inspection of present- day DNA base composition.
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