Molecular Biology and Evolution, Vol 16, 666-675, Copyright © 1999 by Society for Molecular Biology and Evolution
KR Bradnam, C Seoighe, PM Sharp and KH Wolfe
Past analyses of the genome of the yeast Saccharomyces cerevisiae have
revealed substantial regional variation in G+C content. Important questions
remain, though, as to the origin, nature, significance, and generality of
this variation. We conducted an extensive analysis of the yeast genome to
try to answer these questions. Our results indicate that open reading
frames (ORFs) with similar G+C contents at silent codon positions are
significantly clustered on chromosomes. This clustering can be explained by
very short range correlations of silent- site G+C contents at neighboring
ORFs. ORFs of high silent-site G+C content are disproportionately
concentrated on shorter chromosomes, which causes a negative relationship
between chromosome length and G+C content. Contrary to previous reports,
there is no correlation between gene density and silent-site G+C content in
yeast. Chromosome III is atypical in many regards, and possible reasons for
this are discussed.
ORIGINAL ARTICLE
G+C content variation along and among Saccharomyces cerevisiae chromosomes
Division of Genetics, University of Nottingham, United Kingdom.
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