Molecular Biology and Evolution, Vol 16, 619-626, Copyright © 1999 by Society for Molecular Biology and Evolution
TR Schmidt, M Goodman and LI Grossman
COX VIIa is one of 10 nuclear-encoded subunits of the COX holoenzyme, and
one of three that have isoforms with tissue-specific differences in
expression. Analysis of nucleotide substitution rates revealed an
accelerated rate of nonsynonymous substitutions relative to that of
synonymous substitutions for the heart isoform gene (COX7AH) in six primate
lineages. Rate accelerations have been noted for four other COX- related
genes in this time period, suggesting that the COX holoenzyme has
experienced an episode of adaptive evolution. A third member of the gene
family, COX7AR, has recently been described. Although its function is
currently unknown, low nonsynonymous substitution/synonymous substitution
(N/S) ratios in mammalian evolution suggest that COX7AR is of functional
importance. When the COX7A isoforms were divided into domains, examination
of nucleotide substitution rates suggested that mitochondrial targeting
residues experienced an accelerated nonsynonymous substitution rate in the
period following gene duplication. In contrast, paralogous comparisons of
the targeting residues of each isoform show they have been relatively
conserved in mammalian evolution. This pattern is consistent with the
evolution of tissue-specific function.
ORIGINAL ARTICLE
Molecular evolution of the COX7A gene family in primates
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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