Molecular Biology and Evolution, Vol 16, 602-610, Copyright © 1999 by Society for Molecular Biology and Evolution
D Bachtrog, S Weiss, B Zangerl, G Brem and C Schlotterer
Microsatellites, a special class of repetitive DNA, have become one of the
most popular genetic markers. The progress of various genome projects has
made it possible to study the genomic distribution of microsatellites and
to evaluate the potential influence of several parameters on their genesis.
We report the distribution of dinucleotide microsatellites in the genome of
Drosophila melanogaster. When considering only microsatellites with five or
more repeat units, the average length of dinucleotide repeats in D.
melanogaster is 6.7 repeats. We tested a wide range of parameters which
could potentially influence microsatellite density, and we did not detect a
significant influence of recombination rate, number of exons, or total
length of coding sequence. In concordance with the neutral expectation for
the origin of microsatellites, a significant positive correlation between
AT content and (AT/TA)n microsatellite density was detected. While this
pattern may indicate that microsatellite genesis is a random process, we
also found evidence for a nonrandom distribution of microsatellites.
Average microsatellite density was higher on the X chromosome, but extreme
heterogeneity was observed between different genomic regions. Such a
clumping of microsatellites was also evident on a more local scale, as
38.9% of the contiguous sequences analyzed showed a deviation from a random
distribution of microsatellites.
ORIGINAL ARTICLE
Distribution of dinucleotide microsatellites in the Drosophila melanogaster genome
Institut fur Tierzucht und Genetik, Vienna, Austria.
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