Molecular Biology and Evolution, Vol 16, 405-409, Copyright © 1999 by Society for Molecular Biology and Evolution
EC Holmes, M Worobey and A Rambaut
A split decomposition analysis of dengue (DEN) virus gene sequences
revealed extensive networked evolution, indicative of recombination, among
DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within
DEN-1, two viruses sampled from South America in the last 10 years were
identified as recombinants. To map the breakpoints and test their
statistical support, we developed a novel maximum likelihood method. In
both recombinants, the breakpoints were found to be in similar positions,
within the fusion peptide of the envelope protein, demonstrating that a
single recombination event occurred prior to the divergence of these two
strains. This is the first report of recombination in natural populations
of dengue virus.
ORIGINAL ARTICLE
Phylogenetic evidence for recombination in dengue virus
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, U.K. Edward.Holmes@zoo.ox.ac.uk
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