Molecular Biology and Evolution, Vol 16, 347-353, Copyright © 1999 by Society for Molecular Biology and Evolution
V Benassi, F Depaulis, GK Meghlaoui and M Veuille
Departure of molecular variation from neutral equilibrium was studied in a
highly recombining region of the Drosophila genome. A 2.2-kb region
including the Fbp2 locus was sequenced for 10 chromosomes from a D.
melanogaster sample from West Africa and for the related species D.
simulans. Of the 33 variable sites present in the 1.3-kb transcription
unit, 32 made up a single haplotype present in half of the D. melanogaster
sample. This pattern significantly departed from predictions of the neutral
drift-mutation equilibrium model. The major haplotype presented a
diagnostic restriction site which was investigated in 226 chromosomes from
three distant European and African populations. It was found at a high
frequency (31%) in the population from which the sequenced sample
originated, but was nearly absent from the other two (below 4%), suggesting
that the major haplotype frequency resulted from a local selective sweep
event. Partial sweeping of variation in regions of high recombination rates
has previously been found for American and European populations of D.
melanogaster. Our study shows that this phenomenon also occurs in African
populations, which are in the ancestral range of this species.
ORIGINAL ARTICLE
Partial sweeping of variation at the Fbp2 locus in a west African population of Drosophila melanogaster
Laboratoire d'Ecologie, EPHE, Universite Pierre-et-Marie-Curie, Paris, France.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. D. Meiklejohn, Y. Kim, D. L. Hartl, and J. Parsch Identification of a Locus Under Complex Positive Selection in Drosophila simulans by Haplotype Mapping and Composite-Likelihood Estimation Genetics, September 1, 2004; 168(1): 265 - 279. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Palaisa, M. Morgante, S. Tingey, and A. Rafalski Long-range patterns of diversity and linkage disequilibrium surrounding the maize Y1 gene are indicative of an asymmetric selective sweep PNAS, June 29, 2004; 101(26): 9885 - 9890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. S. Balakirev and F. J. Ayala Nucleotide Variation of the Est-6 Gene Region in Natural Populations of Drosophila melanogaster Genetics, December 1, 2003; 165(4): 1901 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Palaisa, M. Morgante, M. Williams, and A. Rafalski Contrasting Effects of Selection on Sequence Diversity and Linkage Disequilibrium at Two Phytoene Synthase Loci PLANT CELL, August 1, 2003; 15(8): 1795 - 1806. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Gomez and E. Hasson Transpecific Polymorphisms in an Inversion Linked Esterase Locus in Drosophila buzzatii Mol. Biol. Evol., March 1, 2003; 20(3): 410 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Saez, A. Tatarenkov, E. Barrio, N. H. Becerra, and F. J. Ayala Patterns of DNA sequence polymorphism at Sod vicinities in Drosophila melanogaster: Unraveling the footprint of a recent selective sweep PNAS, February 18, 2003; 100(4): 1793 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mousset, L. Brazier, M.-L. Cariou, F. Chartois, F. Depaulis, and M. Veuille Evidence of a High Rate of Selective Sweeps in African Drosophila melanogaster Genetics, February 1, 2003; 163(2): 599 - 609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kim and W. Stephan Detecting a Local Signature of Genetic Hitchhiking Along a Recombining Chromosome Genetics, February 1, 2002; 160(2): 765 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kauer, B. Zangerl, D. Dieringer, and C. Schlotterer Chromosomal Patterns of Microsatellite Variability Contrast Sharply in African and Non-African Populations of Drosophila melanogaster Genetics, January 1, 2002; 160(1): 247 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Parsch, C. D. Meiklejohn, and D. L. Hartl Patterns of DNA Sequence Variation Suggest the Recent Action of Positive Selection in the janus-ocnus Region of Drosophila simulans Genetics, October 1, 2001; 159(2): 647 - 657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Andolfatto Contrasting Patterns of X-Linked and Autosomal Nucleotide Variation in Drosophila melanogaster and Drosophila simulans Mol. Biol. Evol., March 1, 2001; 18(3): 279 - 290. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Kim and W. Stephan Joint Effects of Genetic Hitchhiking and Background Selection on Neutral Variation Genetics, July 1, 2000; 155(3): 1415 - 1427. [Abstract] [Full Text]
|
|
|
|
|
|
N. Galtier, F. Depaulis, and N. H. Barton Detecting Bottlenecks and Selective Sweeps From DNA Sequence Polymorphism Genetics, June 1, 2000; 155(2): 981 - 987. [Abstract] [Full Text]
|
|
|
|
|
|
P. Andolfatto and M. Kreitman Molecular Variation at the In(2L)t Proximal Breakpoint Site in Natural Populations of Drosophila melanogaster and D. simulans Genetics, April 1, 2000; 154(4): 1681 - 1691. [Abstract] [Full Text]
|
|
|
|
|
|
P. Andolfatto, J. D. Wall, and M. Kreitman Unusual Haplotype Structure at the Proximal Breakpoint of In(2L)t in a Natural Population of Drosophila melanogaster Genetics, November 1, 1999; 153(3): 1297 - 1311. [Abstract] [Full Text]
|
|
|
|
|
|
F. Depaulis, L. Brazier, and M. Veuille Selective Sweep at the Drosophila melanogaster Suppressor of Hairless Locus and Its Association With the In(2L)t Inversion Polymorphism Genetics, July 1, 1999; 152(3): 1017 - 1024. [Abstract] [Full Text]
|
|