Molecular Biology and Evolution, Vol 16, 1791-1798, Copyright © 1999 by Society for Molecular Biology and Evolution
JK Pritchard, MT Seielstad, A Perez-Lezaun and MW Feldman
We use variation at a set of eight human Y chromosome microsatellite loci
to investigate the demographic history of the Y chromosome. Instead of
assuming a population of constant size, as in most of the previous work on
the Y chromosome, we consider a model which permits a period of recent
population growth. We show that for most of the populations in our sample
this model fits the data far better than a model with no growth. We
estimate the demographic parameters of this model for each population and
also the time to the most recent common ancestor. Since there is some
uncertainty about the details of the microsatellite mutation process, we
consider several plausible mutation schemes and estimate the variance in
mutation size simultaneously with the demographic parameters of interest.
Our finding of a recent common ancestor (probably in the last 120,000
years), coupled with a strong signal of demographic expansion in all
populations, suggests either a recent human expansion from a small
ancestral population, or natural selection acting on the Y chromosome.
ORIGINAL ARTICLE
Population growth of human Y chromosomes: a study of Y chromosome microsatellites
Department of Biological Sciences, Stanford University. pritch@stats.ox.ac.uk
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