Molecular Biology and Evolution, Vol 16, 1503-1510, Copyright © 1999 by Society for Molecular Biology and Evolution
D Nouaud, B Boeda, L Levy and D Anxolabehere
We report evidence supporting the hypothesis that some introns could be
originated from transposable elements. In the Drosophila montium species
subgroup, we recently described a novel example of domestication by the
host genome of a P transposable element. The element is a unique truncated
P sequence transcribed into a polyadenylated RNA encoding a putative 66-kDa
transposition repressor- like protein. Here, we analyze the genomic
modifications associated with this transition of a transposable element
into a stationary gene that is useful for the host. Study of the
transcription modalities of this neogene reveals that the new
transcriptional unit harbors a de novo synthesis of a new exon and a new
intron upstream of the original P sequence initiation site. The new exon
was constructed from the genomic flanking sequence of the P sequence,
whereas the first half of the new intron is composed of genomic flanking
sequence and the second half is composed of P sequence. This domestication
event has involved the capture of a new promoter. An investigation of a
large number of species belonging to the melanogaster species group
revealed that this P element domestication is restricted to the species of
the montium subgroup and that the new exon-intron structure is present in
at least three other species. From sequence data, we hypothesize that
cryptic acceptor and donor splicing sites present on the P element and
flanking sequences have been under selective constraints which have led to
the emergence of a new intron.
ORIGINAL ARTICLE
A P element has induced intron formation in Drosophila
Institut Jacques Monod, Universite P. et M. Curie, Paris, France.
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