Molecular Biology and Evolution, Vol 16, 1466-1473, Copyright © 1999 by Society for Molecular Biology and Evolution
AD Greenwood, C Capelli, G Possnert and S Paabo
We report the retrieval and characterization of multi- and single-copy
nuclear DNA sequences from Alaskan and Siberian mammoths (Mammuthus
primigenius). In addition, a nuclear copy of a mitochondrial gene was
recovered. Furthermore, a 13,000-year-old ground sloth and a 33,000-
year-old cave bear yielded multicopy nuclear DNA sequences. Thus, multicopy
and single-copy genes can be analyzed from Pleistocene faunal remains. The
results also show that under some circumstances, nucleotide sequence
differences between alleles found within one individual can be
distinguished from DNA sequence variation caused by postmortem DNA damage.
The nuclear sequences retrieved from the mammoths suggest that mammoths
were more similar to Asian elephants than to African elephants.
ORIGINAL ARTICLE
Nuclear DNA sequences from late Pleistocene megafauna
Max-Planck-Institute for Evolutionary Anthropology, Leipzig, Germany. alexgr@amnh.org.
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