Molecular Biology and Evolution, Vol 15, 988-996, Copyright © 1998 by Society for Molecular Biology and Evolution
S Cirera and M Aguade
In Drosophila melanogaster, the Acp70A gene, which is involved in the
postmating reactions of the female, is a single-copy gene. However, in
Drosophila subobscura, the gene is duplicated and both copies are
transcribed. To study the molecular evolution of the duplication, a 2.1- kb
fragment encompassing both copies of the duplication was sequenced for 10
lines of D. subobscura and one line of Drosophila madeirensis. Estimates of
the divergence between the two copies of the duplicated region and between
the two species studied, D. subobscura and D. madeirensis, revealed that
both copies of the Acp70a gene had evolved independently since their
duplication. The ratio of nonsynonymous to silent divergence between copies
was generally higher than one. The McDonald and Kreitman test revealed an
excess of nonsynonymous changes fixed since the duplication and before the
split of the D. subobscura and D. madeirensis lineages. These results point
to natural selection driving protein evolution after the duplication.
Specifically, adaptive evolution appears to have caused the initial
differentiation between copies of the N-terminal parts of the proteins,
while purifying selection could be responsible for the high conservation of
the C- terminal parts.
ORIGINAL ARTICLE
Molecular evolution of a duplication: the sex-peptide (Acp70A) gene region of Drosophila subobscura and Drosophila madeirensis
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Spain.
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