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Molecular Biology and Evolution, Vol 15, 176-184, Copyright © 1998 by Society for Molecular Biology and Evolution


ORIGINAL ARTICLE

Conservation of locus-specific microsatellite variability across species: a comparison of two Drosophila sibling species, D. melanogaster and D. simulans

B Harr, B Zangerl, G Brem and C Schlotterer
Institut fur Tierzucht und Genetik, Veterinarmedizinische Universitat Wien, Austria.

Fifteen microsatellite loci were studied in Drosophila melanogaster and Drosophila simulans, two closely related sibling species which split 2- 3.5 MYA. Within-species variances in repeat number were found to differ up to 1,000-fold among individual microsatellite loci. A significant correlation of log variances between both species indicated a locus- specific mutation rate of microsatellites. Hence, locus-specific effects are apparently among the major forces influencing microsatellite variation and deserve more consideration in microsatellite analysis.
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