Molecular Biology and Evolution, Vol 15, 71-75, Copyright © 1998 by Society for Molecular Biology and Evolution
JR Macey, JA Schulte 2nd, A Larson and TJ Papenfuss
A tandem duplication of the mitochondrial tRNA(Thr) and tRNA(Pro) genes in
the amphisbaenian reptile Bipes biporus is the first case reported of a
tandem duplication restricted to a single pair of tRNA genes in a
vertebrate mitochondrial genome. Such duplications have been predicted,
however, as intermediate steps in the evolution of observed mitochondrial
genomic rearrangements through errors in light-strand replication. The
tandem duplication reported here is evolutionarily associated with
displacement of the origin for light-strand replication from its typical
location in vertebrate mitochondrial genomes and loss of the dihydrouridine
stem from the tRNA(Cys) gene; these factors implicate light-strand
replicational errors in the tandem duplication of genic regions. Pseudogene
formation in tandemly duplicated sequences appears to be an intermediate
step in genomic rearrangement. However, formation of pseudogenes in the
Bipes mitochondrial genome occurs in a pattern that precludes subsequent
genomic rearrangement. Functional constraints placed on cleavage of
mitochondrial transcripts by tRNA genes also may prevent mitochondrial
genomic rearrangement.
ORIGINAL ARTICLE
Tandem duplication via light-strand synthesis may provide a precursor for mitochondrial genomic rearrangement
Department of Biology, Washington University, St. Louis, Missouri 63130, USA.
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