Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (12)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Jarne, P.
Right arrow Articles by Viard, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jarne, P.
Right arrow Articles by Viard, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution, Vol 15, 28-34, Copyright © 1998 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Microsatellites, transposable elements and the X chromosome

P Jarne, P David and F Viard
Institut des Sciences de l'Evolution, Universite Montpellier II, France. jarne@isem.univ-montp2.fr

Variability at microsatellite (MS) loci is generally perceived as resulting from an interaction between mutation and genetic drift and, to a lesser extent, selection and recombination. Less investigated has been the reason for MS accumulation in genomes. We present here a simple model that could account for the variation in density of MS loci, assuming that they are created either through replication slippage or in association with transposable elements. Microsatellites then evolve under the forces cited above. We use this framework to revisit two results obtained from high-density genomic maps of the human and mouse genomes built with thousands of CA repeats: MS loci are (1) less variable and (2) less dense on the X chromosome than on autosomes. The first result is most likely explained by differential mutation on the X chromosome and the autosomes. The second result may be explained by differential mutation, provided the distributions of MS loci are still not at equilibrium. Selection, acting either directly on large allele size or indirectly on the transposable elements associated with MS, may explain the same result. The framework developed here is a first step toward more rigorous models, calling for additional data.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
A. M. Rezende, E. Tarazona-Santos, A. D A. Couto, C. J. F. Fontes, J. M. De Souza, L. H. Carvalho, and C. F. A. Brito
Analysis of Genetic Variability of Plasmodium vivax Isolates from Different Brazilian Amazon Areas Using Tandem Repeats
Am J Trop Med Hyg, May 1, 2009; 80(5): 729 - 733.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
J. A. McNeil, K. P. Smith, L. L. Hall, and J. B. Lawrence
Word frequency analysis reveals enrichment of dinucleotide repeats on the human X chromosome and [GATA]n in the X escape region
Genome Res., April 1, 2006; 16(4): 477 - 484.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
M. D. Prasad, M. Muthulakshmi, M. Madhu, S. Archak, K. Mita, and J. Nagaraju
Survey and Analysis of Microsatellites in the Silkworm, Bombyx mori: Frequency, Distribution, Mutations, Marker Potential and Their Conservation in Heterologous Species
Genetics, January 1, 2005; 169(1): 197 - 214.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
C. Rizzon, G. Marais, M. Gouy, and C. Biemont
Recombination Rate and the Distribution of Transposable Elements in the Drosophila melanogaster Genome
Genome Res., March 1, 2002; 12(3): 400 - 407.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.