Molecular Biology and Evolution, Vol 14, 544-549, Copyright © 1997 by Society for Molecular Biology and Evolution
SC Tsaur and CI Wu
The gene for a male ejaculatory protein, Acp26Aa, in four sibling species
of the Drosophila melanogaster subgroup has previously been shown to have a
nonsynonymous rate (Ka) of nucleotide substitution that is
indistinguishable from the synonymous rate (Ks). By examining this gene in
two other species of this subgroup, we found that Ka is generally large and
can sometimes be more than twice as large as Ks. This suggests that
positive selection may be operating at this locus of male reproduction.
ORIGINAL ARTICLE
Positive selection and the molecular evolution of a gene of male reproduction, Acp26Aa of Drosophila
Department of Ecology and Evolution, University of Chicago, IIIinois 60637, USA.
![]()
CiteULike
Connotea
Del.icio.us What's this?
This article has been cited by other articles:
![]() |
M. F. Wolfner Battle and Ballet: Molecular Interactions between the Sexes in Drosophila J. Hered., July 1, 2009; 100(4): 399 - 410. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. A. McGraw, A. G. Clark, and M. F. Wolfner Post-mating Gene Expression Profiles of Female Drosophila melanogaster in Response to Time and to Four Male Accessory Gland Proteins Genetics, July 1, 2008; 179(3): 1395 - 1408. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Wong, M. C. Turchin, M. F. Wolfner, and C. F. Aquadro Evidence for Positive Selection on Drosophila melanogaster Seminal Fluid Protease Homologs Mol. Biol. Evol., March 1, 2008; 25(3): 497 - 506. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Haerty, S. Jagadeeshan, R. J. Kulathinal, A. Wong, K. Ravi Ram, L. K. Sirot, L. Levesque, C. G. Artieri, M. F. Wolfner, A. Civetta, et al. Evolution in the Fast Lane: Rapidly Evolving Sex-Related Genes in Drosophila Genetics, November 1, 2007; 177(3): 1321 - 1335. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J. Wagstaff and D. J. Begun Adaptive Evolution of Recently Duplicated Accessory Gland Protein Genes in Desert Drosophila Genetics, October 1, 2007; 177(2): 1023 - 1030. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Ravi Ram and M. F. Wolfner Seminal influences: Drosophila Acps and the molecular interplay between males and females during reproduction Integr. Comp. Biol., September 1, 2007; 47(3): 427 - 445. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bjork, W. T Starmer, D. M Higginson, C. J Rhodes, and S. Pitnick Complex interactions with females and rival males limit the evolution of sperm offence and defence Proc R Soc B, July 22, 2007; 274(1619): 1779 - 1788. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Wong, S. N. Albright, and M. F. Wolfner Evidence for structural constraint on ovulin, a rapidly evolving Drosophila melanogaster seminal protein PNAS, December 5, 2006; 103(49): 18644 - 18649. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Proschel, Z. Zhang, and J. Parsch Widespread Adaptive Evolution of Drosophila Genes With Sex-Biased Expression Genetics, October 1, 2006; 174(2): 893 - 900. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Metta, R. Gudavalli, J.-M. Gibert, and C. Schlotterer No Accelerated Rate of Protein Evolution in Male-Biased Drosophila pseudoobscura Genes Genetics, September 1, 2006; 174(1): 411 - 420. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. M. Turner and H. E. Hoekstra Adaptive Evolution of Fertilization Proteins within a Genus: Variation in ZP2 and ZP3 in Deer Mice (Peromyscus) Mol. Biol. Evol., September 1, 2006; 23(9): 1656 - 1669. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Andres, L. S. Maroja, S. M. Bogdanowicz, W. J. Swanson, and R. G. Harrison Molecular Evolution of Seminal Proteins in Field Crickets Mol. Biol. Evol., August 1, 2006; 23(8): 1574 - 1584. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. Begun, H. A. Lindfors, M. E. Thompson, and A. K. Holloway Recently Evolved Genes Identified From Drosophila yakuba and D. erecta Accessory Gland Expressed Sequence Tags Genetics, March 1, 2006; 172(3): 1675 - 1681. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. M Panhuis, N. L Clark, and W. J Swanson Rapid evolution of reproductive proteins in abalone and Drosophila Phil Trans R Soc B, February 28, 2006; 361(1466): 261 - 268. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. L Clark, J. E Aagaard, and W. J Swanson Evolution of reproductive proteins from animals and plants Reproduction, January 1, 2006; 131(1): 11 - 22. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J. Wagstaff and D. J. Begun Molecular Population Genetics of Accessory Gland Protein Genes and Testis-Expressed Genes in Drosophila mojavensis and D. arizonae Genetics, November 1, 2005; 171(3): 1083 - 1101. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. B. DuMont and C. F. Aquadro Multiple Signatures of Positive Selection Downstream of Notch on the X Chromosome in Drosophila melanogaster Genetics, October 1, 2005; 171(2): 639 - 653. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. Begun and H. A. Lindfors Rapid Evolution of Genomic Acp Complement in the melanogaster Subgroup of Drosophila Mol. Biol. Evol., October 1, 2005; 22(10): 2010 - 2021. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Mueller, K. R. Ram, L. A. McGraw, M. C. Bloch Qazi, E. D. Siggia, A. G. Clark, C. F. Aquadro, and M. F. Wolfner Cross-Species Comparison of Drosophila Male Accessory Gland Protein Genes Genetics, September 1, 2005; 171(1): 131 - 143. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. M. Hambuch and J. Parsch Patterns of Synonymous Codon Usage in Drosophila melanogaster Genes With Sex-Biased Expression Genetics, August 1, 2005; 170(4): 1691 - 1700. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. J. Wagstaff and D. J. Begun Comparative Genomics of Accessory Gland Protein Genes in Drosophila melanogaster and D. pseudoobscura Mol. Biol. Evol., April 1, 2005; 22(4): 818 - 832. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. H. Thomas, J. L. Kelley, H. M. Robertson, K. Ly, and W. J. Swanson Adaptive evolution in the SRZ chemoreceptor families of Caenorhabditis elegans and Caenorhabditis briggsae PNAS, March 22, 2005; 102(12): 4476 - 4481. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. G. Torgerson and R. S. Singh Rapid Evolution Through Gene Duplication and Subfunctionalization of the Testes-Specific {alpha}4 Proteasome Subunits in Drosophila Genetics, November 1, 2004; 168(3): 1421 - 1432. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. J. Swanson, A. Wong, M. F. Wolfner, and C. F. Aquadro Evolutionary Expressed Sequence Tag Analysis of Drosophila Female Reproductive Tracts Identifies Genes Subjected to Positive Selection Genetics, November 1, 2004; 168(3): 1457 - 1465. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. Zhang, T. M. Hambuch, and J. Parsch Molecular Evolution of Sex-Biased Genes in Drosophila Mol. Biol. Evol., November 1, 2004; 21(11): 2130 - 2139. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. L. Mueller, D. R. Ripoll, C. F. Aquadro, and M. F. Wolfner Comparative structural modeling and inference of conserved protein classes in Drosophila seminal fluid PNAS, September 14, 2004; 101(37): 13542 - 13547. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Sun, C.-T. Ting, and C.-I Wu The Normal Function of a Speciation Gene, Odysseus, and Its Hybrid Sterility Effect Science, July 2, 2004; 305(5680): 81 - 83. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. D. Kern, C. D. Jones, and D. J. Begun Molecular Population Genetics of Male Accessory Gland Proteins in the Drosophila simulans Complex Genetics, June 1, 2004; 167(2): 725 - 735. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. Wang and J. Zhang Rapid Evolution of Mammalian X-Linked Testis-Expressed Homeobox Genes Genetics, June 1, 2004; 167(2): 879 - 888. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Sawamura, J. Roote, C.-I Wu, and M.-T. Yamamoto Genetic Complexity Underlying Hybrid Male Sterility in Drosophila Genetics, February 1, 2004; 166(2): 789 - 796. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. H. Kohn, S. Fang, and C.-I Wu Inference of Positive and Negative Selection on the 5' Regulatory Regions of Drosophila Genes Mol. Biol. Evol., February 1, 2004; 21(2): 374 - 383. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Tamura, S. Subramanian, and S. Kumar Temporal Patterns of Fruit Fly (Drosophila) Evolution Revealed by Mutation Clocks Mol. Biol. Evol., January 1, 2004; 21(1): 36 - 44. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. H. Pogson and K. A. Mesa Positive Darwinian Selection at the Pantophysin (Pan I) Locus in Marine Gadid Fishes Mol. Biol. Evol., January 1, 2004; 21(1): 65 - 75. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Podlaha and J. Zhang Positive selection on protein-length in the evolution of a primate sperm ion channel PNAS, October 14, 2003; 100(21): 12241 - 12246. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. J. Swanson Sex peptide and the sperm effect in Drosophila melanogaster PNAS, August 19, 2003; 100(17): 9643 - 9644. [Full Text] [PDF] |
||||
![]() |
T. Chapman, J. Bangham, G. Vinti, B. Seifried, O. Lung, M. F. Wolfner, H. K. Smith, and L. Partridge From the Cover: The sex peptide of Drosophila melanogaster: Female post-mating responses analyzed by using RNA interference PNAS, August 19, 2003; 100(17): 9923 - 9928. [Abstract] [Full Text] [PDF] |
||||
![]() |
U. Sorhannus The Effect of Positive Selection on a Sexual Reproduction Gene in Thalassiosira weissflogii (Bacillariophyta): Results Obtained from Maximum-Likelihood and Parsimony-Based Methods Mol. Biol. Evol., August 1, 2003; 20(8): 1326 - 1328. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. S. Zigler and H. A. Lessios Evolution of Bindin in the Pantropical Sea Urchin Tripneustes: Comparisons to Bindin of Other Genera Mol. Biol. Evol., February 1, 2003; 20(2): 220 - 231. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Civetta Positive Selection Within Sperm-Egg Adhesion Domains of Fertilin: An ADAM Gene with a Potential Role in Fertilization Mol. Biol. Evol., January 1, 2003; 20(1): 21 - 29. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. J. Wyckoff, J. Li, and C.-I Wu Molecular Evolution of Functional Genes on the Mammalian Y Chromosome Mol. Biol. Evol., September 1, 2002; 19(9): 1633 - 1636. [Full Text] [PDF] |
||||
![]() |
O. Lung, U. Tram, C. M. Finnerty, M. A. Eipper-Mains, J. M. Kalb, and M. F. Wolfner The Drosophila melanogaster Seminal Fluid Protein Acp62F Is a Protease Inhibitor That Is Toxic Upon Ectopic Expression Genetics, January 1, 2002; 160(1): 211 - 224. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Parsch, C. D. Meiklejohn, and D. L. Hartl Patterns of DNA Sequence Variation Suggest the Recent Action of Positive Selection in the janus-ocnus Region of Drosophila simulans Genetics, October 1, 2001; 159(2): 647 - 657. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. J. Swanson, A. G. Clark, H. M. Waldrip-Dail, M. F. Wolfner, and C. F. Aquadro Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila PNAS, June 7, 2001; (2001) 131568198. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Parsch, C. D. Meiklejohn, E. Hauschteck-Jungen, P. Hunziker, and D. L. Hartl Molecular Evolution of the ocnus and janus Genes in the Drosophila melanogaster Species Subgroup Mol. Biol. Evol., May 1, 2001; 18(5): 801 - 811. [Abstract] [Full Text] |
||||
![]() |
W. J. Swanson, C. F. Aquadro, and V. D. Vacquier Polymorphism in Abalone Fertilization Proteins Is Consistent with the Neutral Evolution of the Egg's Receptor for Lysin (VERL) and Positive Darwinian Selection of Sperm Lysin Mol. Biol. Evol., March 1, 2001; 18(3): 376 - 383. [Abstract] [Full Text] |
||||
![]() |
W. J. Swanson, Z. Yang, M. F. Wolfner, and C. F. Aquadro Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals PNAS, February 15, 2001; (2001) 51605998. [Abstract] [Full Text] |
||||
![]() |
S.-C. Tsaur, C.-T. Ting, and C.-I Wu Sex in Drosophila mauritiana: A Very High Level of Amino Acid Polymorphism in a Male Reproductive Protein Gene, Acp26Aa Mol. Biol. Evol., January 1, 2001; 18(1): 22 - 26. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. J. Begun, P. Whitley, B. L. Todd, H. M. Waldrip-Dail, and A. G. Clark Molecular Population Genetics of Male Accessory Gland Proteins in Drosophila Genetics, December 1, 2000; 156(4): 1879 - 1888. [Abstract] [Full Text] |
||||
![]() |
A. Civetta and A. G. Clark Correlated effects of sperm competition and postmating female mortality PNAS, November 8, 2000; (2000) 230305397. [Abstract] [Full Text] |
||||
![]() |
A. Branscomb, J. Seger, and R. L. White Evolution of Odorant Receptors Expressed in Mammalian Testes Genetics, October 1, 2000; 156(2): 785 - 797. [Abstract] [Full Text] |
||||
![]() |
Z. Yang, W. J. Swanson, and V. D. Vacquier Maximum-Likelihood Analysis of Molecular Adaptation in Abalone Sperm Lysin Reveals Variable Selective Pressures Among Lineages and Sites Mol. Biol. Evol., October 1, 2000; 17(10): 1446 - 1455. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. C. Fay and C.-I Wu Hitchhiking Under Positive Darwinian Selection Genetics, July 1, 2000; 155(3): 1405 - 1413. [Abstract] [Full Text] |
||||
![]() |
M. E. Hellberg, G. W. Moy, and V. D. Vacquier Positive Selection and Propeptide Repeats Promote Rapid Interspecific Divergence of a Gastropod Sperm Protein Mol. Biol. Evol., March 1, 2000; 17(3): 458 - 466. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. J. Schmid, L. Nigro, C. F. Aquadro, and D. Tautz Large Number of Replacement Polymorphisms in Rapidly Evolving Genes of Drosophila: Implications for Genome-Wide Surveys of DNA Polymorphism Genetics, December 1, 1999; 153(4): 1717 - 1729. [Abstract] [Full Text] |
||||
![]() |
M. Aguadé Positive Selection Drives the Evolution of the Acp29AB Accessory Gland Protein in Drosophila Genetics, June 1, 1999; 152(2): 543 - 551. [Abstract] [Full Text] |
||||
![]() |
C. Ting, S. Tsaur, M. Wu, and C. Wu A Rapidly Evolving Homeobox at the Site of a Hybrid Sterility Gene Science, November 20, 1998; 282(5393): 1501 - 1504. [Abstract] [Full Text] |
||||
![]() |
M. Aguadé Different Forces Drive the Evolution of the Acp26Aa and Acp26Ab Accessory Gland Genes in the Drosophila melanogaster Species Complex Genetics, November 1, 1998; 150(3): 1079 - 1089. [Abstract] [Full Text] |
||||
![]() |
N. G. C. Smith and L. D. Hurst Molecular Evolution of an Imprinted Gene: Repeatability of Patterns of Evolution Within the Mammalian Insulin-Like Growth Factor Type II Receptor Genetics, October 1, 1998; 150(2): 823 - 833. [Abstract] [Full Text] |
||||
![]() |
L. Partridge and Laurence D. Hurst Sex and Conflict Science, September 25, 1998; 281(5385): 2003 - 2008. [Abstract] [Full Text] |
||||
![]() |
W. J. Swanson and V. D. Vacquier Concerted Evolution in an Egg Receptor for a Rapidly Evolving Abalone Sperm Protein Science, July 31, 1998; 281(5377): 710 - 712. [Abstract] [Full Text] |
||||
![]() |
J. Zhang, H. F. Rosenberg, and M. Nei Positive Darwinian selection after gene duplication in primate ribonuclease genes PNAS, March 31, 1998; 95(7): 3708 - 3713. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. J. Schmid and D. Tautz A screen for fast evolving genes from Drosophila PNAS, September 2, 1997; 94(18): 9746 - 9750. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Sawamura, A. W. Davis, and C.-I Wu Genetic analysis of speciation by means of introgression into Drosophila melanogaster PNAS, March 14, 2000; 97(6): 2652 - 2655. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. J. Swanson, Z. Yang, M. F. Wolfner, and C. F. Aquadro Positive Darwinian selection drives the evolution of several female reproductive proteins in mammals PNAS, February 27, 2001; 98(5): 2509 - 2514. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Zhang, K. D. Dyer, and H. F. Rosenberg Evolution of the rodent eosinophil-associated RNase gene family by rapid gene sorting and positive selection PNAS, April 25, 2000; 97(9): 4701 - 4706. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. J. Swanson, A. G. Clark, H. M. Waldrip-Dail, M. F. Wolfner, and C. F. Aquadro Evolutionary EST analysis identifies rapidly evolving male reproductive proteins in Drosophila PNAS, June 19, 2001; 98(13): 7375 - 7379. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Civetta and A. G. Clark Correlated effects of sperm competition and postmating female mortality PNAS, November 21, 2000; 97(24): 13162 - 13165. [Abstract] [Full Text] [PDF] |
||||








