Molecular Biology and Evolution, Vol 14, 399-411, Copyright © 1997 by Society for Molecular Biology and Evolution
N Saitou and F Yamamoto
There are three common alleles (A, B, and O) at the human ABO blood group
locus. We compared nucleotide sequences of these alleles, and relatively
large numbers of nucleotide differences were found among them. These
differences correspond to the divergence time of at least a few million
years, which is unusually large for a human allelic divergence under
neutral evolution. We constructed phylogenetic networks of human and
nonhuman primate ABO alleles, and at least three independent appearances of
B alleles from the ancestral A form were observed. These results suggest
that some kind of balancing selection may have been operating at the ABO
locus. We also constructed phylogenetic trees of ABO and their
evolutionarily related alpha-1,3- galactosyltransferase genes, and the
divergence time between these two families was estimated to be roughly 400
MYA.
ORIGINAL ARTICLE
Evolution of primate ABO blood group genes and their homologous genes
Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima, Japan. nsaitou@genes.nig.ac.jp
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