Molecular Biology and Evolution, Vol 14, 391-398, Copyright © 1997 by Society for Molecular Biology and Evolution
Z Pancer, M Kruse, I Muller and WE Muller
Integrins are prominent receptors known from vertebrates and the higher
phyla of invertebrates. Until now, no evidence has been provided for the
existence of integrins in the lowest Metazoa, the sponges (Porifera). We
have isolated and characterized a cDNA clone encoding the alpha subunit of
integrin from the marine sponge Geodia cydonium (GCINTEG). The open reading
frame encodes a polypeptide of 1,086 residues (118 kDa). The intracellular
domain features the sequence Tyr- Phe-x-Gly-Phe-Phe-x-Arg, which is
different in one residue from the characteristic consensus pattern for
integrin alpha subunits. We conclude that sponges, the oldest multicellular
animal phylum, already utilize the structural elements which are required
for a tuned and controlled interaction among cells, and between cells and
the extracellular matrix.
ORIGINAL ARTICLE
On the origin of Metazoan adhesion receptors: cloning of integrin alpha subunit from the sponge Geodia cydonium
Abteilung Angewandte Molekularbiologie, Universitat, Mainz, Germany.
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