Molecular Biology and Evolution, Vol 14, 195-199, Copyright © 1997 by Society for Molecular Biology and Evolution
YX Fu and WH Li
We present a simple Monte Carlo method for estimating the age of the most
recent common ancestor (MRCA) of a sample of DNA sequences. We show that
Templeton's (1993) estimator of the age of the MRCA based on the maximum
number of nucleotide differences between two sequences in a sample is
inaccurate, and we demonstrate the new method by reanalyzing a sample of
DNA sequences from human Y chromosomes and a sample of human Alu sequences.
ORIGINAL ARTICLE
Estimating the age of the common ancestor of a sample of DNA sequences
Human Genetics Center, School of Public Health, University of Texas at Houston 77225, USA. fu@hgc.sph.uth.tmc.edu
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