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Molecular Biology and Evolution, Vol 14, 1187-1196, Copyright © 1997 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Evolutionary dynamics of tandem repeats in the mitochondrial DNA control region of the minnow Cyprinella spiloptera

RE Broughton and TE Dowling
Department of Zoology, Arizona State University. reb17@cornell.edu

Length variation due to tandem repeats is now recognized as a common feature of animal mitochondrial DNA; however, the evolutionary dynamics of repeated sequences are not well understood. Using phylogenetic analysis, predictions of three models of repeat evolution were tested for arrays of 260-bp repeats in the cyprinid fish Cyprinella spiloptera. Variation at different nucleotide positions in individual repeats supported different models of repeat evolution. One set of characters included several nucleotide variants found in all copies from a limited number of individuals, while the other set included an 8- bp deletion found in a limited number of copies in all individuals. The deletion and an associated nucleotide change appear to be the result of a deterministic, rather than stochastic, mutation process. Parallel origins of repeat arrays in different mitochondrial lineages, possibly coupled with a homogenization mechanism, best explain the distribution of nucleotide variation.
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This article has been cited by other articles:


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 Mol Biol EvolHome page
P. Savolainen, L. Arvestad, and J. Lundeberg
mtDNA Tandem Repeats in Domestic Dogs and Wolves: Mutation Mechanism Studied by Analysis of the Sequence of Imperfect Repeats
Mol. Biol. Evol., April 1, 2000; 17(4): 474 - 488.
[Abstract] [Full Text] [PDF]


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