Molecular Biology and Evolution, Vol 13, 864-872, Copyright © 1996 by Society for Molecular Biology and Evolution
A Eyre-Walker
The levels of synonymous codon bias is shown to be positively correlated to
gene length in Escherichia coli genes which are thought to be expressed at
similar levels; these are genes whose products are present in multimeric
proteins in equimolar amounts. It is argued that the positive correlation
could be caused by selection to avoid missense errors during translation.
Since the cost of producing a protein is proportional to its length,
selection in favor of codons which increase accuracy should be greater in
longer genes, and long genes should therefore have higher synonymous codon
bias. It is also shown that there is variation in synonymous codon use
which is independent of either expression level, gene length, amino acid
composition, or chromosomal location. This variation is consistent with
selection for translational accuracy but may have other origins.
ORIGINAL ARTICLE
Synonymous codon bias is related to gene length in Escherichia coli: selection for translational accuracy?
Department of Biological Sciences, Rutgers University, New Brunswick, New Jersey 08903, USA. eyrewalker@mbcl.rutgers.edu
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