Molecular Biology and Evolution, Vol 13, 685-690, Copyright © 1996 by Society for Molecular Biology and Evolution
T Endo, K Ikeo and T Gojobori
We conducted a systematic search for the candidate genes on which positive
selection may operate, on the premise that for such genes the number of
nonsynonymous substitution is expected to be larger than that of synonymous
substitutions when the nucleotide sequences of genes under investigation
are compared with each other. By obtaining 3,595 groups of homologous
sequences from the DDBJ, EMBL, and GenBank DNA sequence databases, we found
that 17 gene groups can be the candidates for the genes on which positive
selection may operate. Thus, such genes are found to occupy only about 0.5%
of the vast number of gene groups so far available. Interestingly enough 9
out of the 17 gene groups were the surface antigens of parasites or
viruses.
ORIGINAL ARTICLE
Large-scale search for genes on which positive selection may operate
National Institute of Genetics, Mishima, Japan.
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