Molecular Biology and Evolution, Vol 12, 1063-1073, Copyright © 1995 by Society for Molecular Biology and Evolution
RS Gupta
The heat shock protein (Hsp) sequences, because of their ubiquity and high
degree of conservation, provide useful models for phylogenetic analysis. In
this paper I have carried out a global alignment of all available sequences
(a total of 31) for the 90-kD heat shock protein (Hsp90) family. The
minimum amino acid identity that is seen between presently known Hsp90
homologs is about 40% over the entire length, indicating that it is a
highly conserved protein. Based on the alignment, a number of signature
sequences that either are distinctive of the Hsp90 family or that
distinguish between the cytosolic and the endoplasmic reticular forms of
Hsp90 have been identified. Detailed phylogenetic analyses based on Hsp90
sequences reported here strongly indicate that the cytosolic and the
endoplasmic reticulum (ER) resident forms of Hsp90 constitute paralogous
gene families which arose by a gene duplication event that took place very
early in the evolution of eukaryotic cells. A minimum of two additional
gene duplication events, which took place at a later time, are required to
explain the presence of two different forms of Hsp90 that are found in
fungi and vertebrate species. In a consensus neighbor-joining bootstrap
tree based on Hsp90 sequences, plants and animals species grouped together
989 times of 1,000 (a highly significant score), indicating a closer
relationship between them as compared to fungi. A closer affiliation of
plant and animal species was also observed in the maximum-parsimony tree,
although the relationship was not significantly supported by this method. A
survey of the recent literature on this subject indicates that depending on
the protein sequence and the methods of phylogenetic analysis, the animal
species are indicated as closer relatives to either plants or fungi with
significant statistical support for both topologies. Thus the relationship
among the animal, plant, and fungi kingdoms remains an unresolved issue at
the present time.
ORIGINAL ARTICLE
Phylogenetic analysis of the 90 kD heat shock family of protein sequences and an examination of the relationship among animals, plants, and fungi species
Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada.
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