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Molecular Biology and Evolution, Vol 12, 527-532, Copyright © 1995 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Initial mutational steps toward loss of opsin gene function in cavefish

S Yokoyama, A Meany, H Wilkens and R Yokoyama
Department of Biology, Syracuse University, NY 13244-1220, USA.

The river-dwelling fishes of Astyanax fasciatus and their derivatives from Pachon and Micos caves in Mexico were collected. By comparing red (r007) and green (g103) opsin gene sequences from the three populations, we found a high frequency of C-->T changes in r007 and g103 of the eyed Micos fishes presumably due to spontaneous cytosine methylation or enzymatic deamination of the CG dinucleotide, and a deletion of 12 consecutive nucleotides in g101 of the blind Pachon fishes. Thus, high rates of nucleotide substitution and C-->T transitions, usually found for pseudogenes, may occur even before they become nonfunctional.
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