Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Shyue, S. K.
Right arrow Articles by Li, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shyue, S. K.
Right arrow Articles by Li, W. H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution, Vol 11, 548-551, Copyright © 1994 by Society for Molecular Biology and Evolution

LETTER TO THE EDITOR

Intronic gene conversion in the evolution of human X-linked color vision genes

SK Shyue, L Li, BH Chang and WH Li

Human red and green visual pigment genes are X-linked duplicate genes. To study their evolutionary history, introns 2 and 4 (1,987 and 1,552 bp, respectively) of human red and green pigment genes were sequenced. Surprisingly, we found that intron 4 sequences of these two genes are identical and that the intron 2 sequences differ by only 0.3%. The low divergences are unexpected because the duplication event producing the two genes is believed to have occurred before the separation of the human and Old World monkey (OWM) lineages. Indeed, the divergences in the two introns are significantly lower than both the synonymous divergence (3.2% +/- 1.1%) and the nonsynonymous divergence (2.0% +/- 0.5%) in the coding sequences (exons 1-6). A comparison of partial sequences of exons 4 and 5 of human and OWM red and green pigment genes supports the hypothesis that the gene duplication occurred before the human-OWM split. In conclusion, the high similarities in the two intron sequences might be due to very recent gene conversion, probably during evolution of the human lineage.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol Biol EvolHome page
K. Ezawa, S. OOta, and N. Saitou
Genome-Wide Search of Gene Conversions in Duplicated Genes of Mouse and Rat
Mol. Biol. Evol., May 1, 2006; 23(5): 927 - 940.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. T. Sharpe, A. Stockman, H. Jagle, H. Knau, G. Klausen, A. Reitner, and J. Nathans
Red, Green, and Red-Green Hybrid Pigments in the Human Retina: Correlations between Deduced Protein Sequences and Psychophysically Measured Spectral Sensitivities
J. Neurosci., December 1, 1998; 18(23): 10053 - 10069.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Boissinot, Y. Tan, S.-K. Shyue, H. Schneider, I. Sampaio, K. Neiswanger, D. Hewett-Emmett, and W.-H. Li
Origins and antiquity of X-linked triallelic color vision systems in New World monkeys
PNAS, November 10, 1998; 95(23): 13749 - 13754.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
S. Shyue, D Hewett-Emmett, H. Sperling, D. Hunt, J. Bowmaker, J. Mollon, and W. Li
Adaptive evolution of color vision genes in higher primates
Science, September 1, 1995; 269(5228): 1265 - 1267.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.