Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (19)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Nachman, M. W.
Right arrow Articles by Aquadro, C. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nachman, M. W.
Right arrow Articles by Aquadro, C. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Molecular Biology and Evolution, Vol 11, 539-547, Copyright © 1994 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Polymorphism and divergence at the 5' flanking region of the sex- determining locus, Sry, in mice

MW Nachman and CF Aquadro
Section of Genetics and Development, Cornell University, Ithaca, New York 14853-2703.

We have investigated patterns of evolution in the nonrecombining portion of the Y chromosome in mice by comparing levels of polymorphism within Mus domesticus with levels of divergence between M. domesticus and M. spretus. A 1,277-bp fragment of noncoding sequence flanking the sex determining locus (Sry) was PCR amplified, and 1,063 bases were sequenced and compared among 20 M. domesticus and 1 M. spretus. Two polymorphic base substitutions and two polymorphic insertion/deletion sites were identified within M. domesticus; nucleotide diversity was estimated to be 0.1%. Divergence between M. domesticus and M. spretus for this region (1.9%) was slightly lower than the average divergence of single-copy nuclear DNA for these species. Comparison of levels of polymorphism and divergence at Sry with levels of polymorphism and divergence in the mitochondrial DNA control region provided no evidence of a departure from the expectations of neutral molecular evolution. These findings are consistent with the presumed lack of function for much of the Y chromosome.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
T. Salcedo, A. Geraldes, and M. W. Nachman
Nucleotide Variation in Wild and Inbred Mice
Genetics, December 1, 2007; 177(4): 2277 - 2291.
[Abstract] [Full Text] [PDF]

Home page
 GeneticsHome page
L. J. Lawson Handley, L. Berset-Brandli, and N. Perrin
Disentangling Reasons for Low Y Chromosome Variation in the Greater White-Toothed Shrew (Crocidura russula)
Genetics, June 1, 2006; 173(2): 935 - 942.
[Abstract] [Full Text] [PDF]

Home page
 Mol Biol EvolHome page
P. K. Tucker, R. M. Adkins, and J. S. Rest
Differential Rates of Evolution for the ZFY-Related Zinc Finger Genes, Zfy, Zfx, and Zfa in the Mouse Genus Mus
Mol. Biol. Evol., June 1, 2003; 20(6): 999 - 1005.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.