Molecular Biology and Evolution, Vol 11, 504-512, Copyright © 1994 by Society for Molecular Biology and Evolution
N Saitou and S Ueda
Insertions and deletions are responsible for gaps in aligned nucleotide
sequences, but they have been usually ignored when the number of nucleotide
substitutions was estimated. We compared six sets of nuclear and
mitochondrial noncoding DNA sequences of primates and obtained the
estimates of the evolutionary rate of insertion and deletion. The
maximum-parsimony principle was applied to locate insertions and deletions
on a given phylogenetic tree. Deletions were about twice as frequent as
insertions for nuclear DNA, and single-nucleotide insertions and deletions
were the most frequent in all events. The rate of insertion and deletion
was found to be rather constant among branches of the phylogenetic tree,
and the rate (approximately 2.0/kb/Myr) for mitochondrial DNA was found to
be much higher than that (approximately 0.2/kb/Myr) for nuclear DNA. The
rates of nucleotide substitution were about 10 times higher than the rate
of insertion and deletion for both nuclear and mitochondrial DNA.
ORIGINAL ARTICLE
Evolutionary rates of insertion and deletion in noncoding nucleotide sequences of primates
Laboratory of Evolutionary Genetics, National Institute of Genetics, Mishima Japan.
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