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Molecular Biology and Evolution, Vol 11, 384-392, Copyright © 1994 by Society for Molecular Biology and Evolution

ORIGINAL ARTICLE

Recent evolutionary history of American Onchocerca volvulus, based on analysis of a tandemly repeated DNA sequence family

PA Zimmerman, CR Katholi, MC Wooten, N Lang-Unnasch and TR Unnasch
Department of Medicine, University of Alabama at Birmingham 35294.

Polymerase chain reaction (PCR) products were characterized for a repeated sequence family (designated "O-150") of the human filarial parasite Onchocerca volvulus. In phylogenetic inferences, the O-150 sequences clustered into closely related groups, suggesting that concerted evolution maintains sequence homology in this family. Using a novel mathematical model based on a nested application of an analysis of variance, we demonstrated that African rainforest and savannah strain parasite populations are significantly different. In contrast, parasites collected in the New World are indistinguishable from African savannah strains of O. volvulus. This finding supports the hypothesis that onchocerciasis was recently introduced into the New World, possibly as a result of the slave trade.
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