Molecular Biology and Evolution, Vol 11, 88-98, Copyright © 1994 by Society for Molecular Biology and Evolution
A Eyre-Walker
It has been suggested that the differences in synonymous codon use between
mammalian genes within a genome are due to differences in the efficiency of
DNA mismatch repair. This hypothesis was tested by developing a model of
mismatch repair, which was used to predict the expected relationship
between the rate of substitution and G+C content at silent sites. It was
found that the silent-substitution rate should decline with increasing G+C
content over most of the G+C-content range, if it is assumed that mismatch
repair is G+C biased, an assumption which is supported by data. This
prediction was then tested on a set of 58 primate and artiodactyl genes.
There was no evidence of a direct decline in substitution rate with
increasing G+C content, for either twofold- or fourfold-degenerate sites.
It was therefore concluded that variation in the efficiency of mismatch
repair is not responsible for the differences in synonymous codon use
between mammalian genes. In support of this conclusion, analysis of the
model also showed that the parameter range over which mismatch repair can
explain the differences in synonymous codon use between genes is very
small.
ORIGINAL ARTICLE
DNA mismatch repair and synonymous codon evolution in mammals
Institute of Cell, Animal and Population Biology, University of Edinburgh.
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