Molecular Biology and Evolution, Vol 11, 51-64, Copyright © 1994 by Society for Molecular Biology and Evolution
DA Caporale and TD Kocher
Borrelia burgdorferi is a spirochete pathogen transmitted among warm-
blooded hosts by ixodid ticks. Frequency-dependent selection for variant
outer-surface proteins might be expected to arise in this species, since
rare variants are more likely to avoid immune surveillance in previously
infected hosts. We sequenced the OspA and OspB genes of nine North American
strains and compared them with nine strains previously described. For each
gene, the mean number of synonymous substitutions per synonymous site and
the mean number of nonsynonymous substitutions per nonsynonymous site show
only a twofold excess of silent mutations. Synonymous rates vary widely
along the OspB protein. Some regions show a significant excess of silent
substitutions, while divergence in other regions is constrained by biased
base composition or selection. The presence, in antigenically important
regions of the protein, of significant variation among strains, as well as
evidence for recombination among strains, should be considered in attempts
to develop vaccines against this disease.
ORIGINAL ARTICLE
Sequence variation in the outer-surface-protein genes of Borrelia burgdorferi
Department of Zoology, University of New Hampshire, Durham 03824.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L.-L. Chao, W.-J. Wu, and C.-M. Shih First Detection and Molecular Identification of Borrelia burgdorferi-like Spirochetes in Ixodes granulatus Ticks Collected on Kinmen Island of Taiwan Am J Trop Med Hyg, March 1, 2009; 80(3): 389 - 394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Anderson and D. E. Norris Genetic Diversity of Borrelia burgdorferi Sensu Stricto in Peromyscus leucopus, the Primary Reservoir of Lyme Disease in a Region of Endemicity in Southern Maryland Appl. Envir. Microbiol., August 1, 2006; 72(8): 5331 - 5341. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. E. Hagman, X. Yang, S. K. Wikel, G. B. Schoeler, M. J. Caimano, J. D. Radolf, and M. V. Norgard Decorin-Binding Protein A (DbpA) of Borrelia burgdorferi Is Not Protective When Immunized Mice Are Challenged via Tick Infestation and Correlates with the Lack of DbpA Expression by B. burgdorferi in Ticks Infect. Immun., August 1, 2000; 68(8): 4759 - 4764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I.-N. Wang, D. E. Dykhuizen, W. Qiu, J. J. Dunn, E. M. Bosler, and B. J. Luft Genetic Diversity of ospC in a Local Population of Borrelia burgdorferi sensu stricto Genetics, January 1, 1999; 151(1): 15 - 30. [Abstract] [Full Text]
|
|
|
|
|
|
K. E. Hagman, P. Lahdenne, T. G. Popova, S. F. Porcella, D. R. Akins, J. D. Radolf, and M. V. Norgard Decorin-Binding Protein of Borrelia burgdorferi Is Encoded within a Two-Gene Operon and Is Protective in the Murine Model of Lyme Borreliosis Infect. Immun., June 1, 1998; 66(6): 2674 - 2683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sreevatsan, X. Pan, K. E. Stockbauer, N. D. Connell, B. N. Kreiswirth, T. S. Whittam, and J. M. Musser Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination PNAS, September 2, 1997; 94(18): 9869 - 9874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Donelson and J. E. Donelson Mechanisms of Antigenic Variation in Borrelia hermsii and African Trypanosomes J. Biol. Chem., April 7, 1995; 270(14): 7783 - 7786. [Full Text] [PDF]
|
|