Molecular Biology and Evolution, Vol 10, 1396-1401, Copyright © 1993 by Society for Molecular Biology and Evolution
Z Yang
Felsenstein's maximum-likelihood approach for inferring phylogeny from DNA
sequences assumes that the rate of nucleotide substitution is constant over
different nucleotide sites. This assumption is sometimes unrealistic, as
has been revealed by analysis of real sequence data. In the present paper
Felsenstein's method is extended to the case where substitution rates over
sites are described by the gamma distribution. A numerical example is
presented to show that the method fits the data better than do previous
models.
ORIGINAL ARTICLE
Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites
Department of Animal Science, Beijing Agricultural University.
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