Molecular Biology and Evolution, Vol 10, 1327-1342, Copyright © 1993 by Society for Molecular Biology and Evolution
YX Zhang, JG Fox, Y Ho, L Zhang, HF Stills Jr and TF Smith
Restriction fragments containing the major outer-membrane protein (MOMP)
gene from two nonhuman (rodent) strains of Chlamydia trachomatis, the mouse
pneumonitis (MoPn) strain and the SFPD strain isolated from hamsters with
transmissible proliferative ileitis, were cloned and sequenced. The MOMP
genes of both MoPn and SFPD encode an identical 22-amino acid leader
peptide and mature polypeptides of 365 and 382 amino acids, respectively.
Alignment of the MOMP genes of the two rodent strains revealed 91%
identity. By comparison with other known chlamydial MOMP gene sequences,
there was 80%-83% identity with human biovars strains of C. trachomatis,
and there was 69%-70% identity with C. psittaci and C. pneumoniae strains.
The main differences in these sequences were clustered into four variable
domains. A minimum- length evolutionary tree was constructed on the basis
of the MOMP gene variable positions by using PIMA package software. The
minimum mutation distances indicated that (i) the MOMP genes of all
chlamydial strains may have evolved from a common ancestor; (ii) all the
strains of C. trachomatis compose one of the subtrees, and strains of C.
psittaci and C. pneumoniae compose the other subtree; and (iii) in the C.
trachomatis subtree, the human and the rodent strains are divided into two
clusters. The branching pattern of this evolutionary tree is generally
consistent with current classification based on serological, morphological,
and other biological characteristics.
ORIGINAL ARTICLE
Comparison of the major outer-membrane protein (MOMP) gene of mouse pneumonitis (MoPn) and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strains
Maxwell Finland Laboratory for Infectious Diseases, Boston City Hospital, Boston University School of Medicine, Massachusetts.
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