Molecular Biology and Evolution, Vol 10, 1136-1149, Copyright © 1993 by Society for Molecular Biology and Evolution
P Djian, M Phillips, K Easley, E Huang, M Simon, RH Rice and H Green
The involucrin genes of the mouse (Mus musculus) and the rat (Rattus
norvegicus) have been cloned and sequenced. The coding region of each gene
contains, at site P, a segment of repeats homologous to that of other
nonanthropoid mammals. In contrast to the repeats of species belonging to
different mammalian orders, many individual repeats of the mouse and the
rat can be matched. Both before and after the divergence of the two
species, these repeats have been the site of systematic alterations in
nucleotide sequence. One of the alterations is the correction of
nucleotides of one repeat by those of another. Corrected nucleotides may be
closely linked to flanking nucleotides that are uncorrected; the systematic
correction process therefore appears to be due to gene conversion. There is
a stretch of 18 reiterated CAGs in the segment of repeats of the Mus gene;
most of these reiterations were introduced recently, supporting the idea
that the gene was generated originally from poly CAG. An antiserum to a
synthetic peptide encoded by the segment of repeats of the Mus gene reveals
differentiation- specific expression of the gene in the epidermis.
ORIGINAL ARTICLE
The involucrin genes of the mouse and the rat: study of their shared repeats
Department of Cellular and Molecular Physiology, Harvard Medical School, Boston, Massachusetts 02115.
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